146422-58-4
146422-58-4 結構式
基本信息
中文別名
化合物 T10731 英文別名
CDD0102CDD0102A
Pyrimidine, 5-(3-ethyl-1,2,4-oxadiazol-5-yl)-1,4,5,6-tetrahydro-
常見問題列表
生物活性
CDD0102 是一種有效的 M1 毒蕈堿 (Muscarinic) 受體激動劑。靶點
mAChR
體外研究
CDD0102 (CDD-0102) is an efficacious muscarinic agonist in cell lines expressing M 1 receptors. CDD0102 displays much lower activity at M 3 and M 5 receptors.
體內研究
After i.p. injections, CDD0102 (CDD-0102) crosses the blood-brain barrier (BBB) in a dose-dependent manner. In toxicological studies, the LD 50 of CDD0102 is 190 mg/kg following i.p. injections and greater than 1,000 mg/kg following oral administration. In follow-up studies, after oral administration at a dose of 10 mg/kg, CDD0102 fully reverses memory deficits associated with IgG-192 saporin administration. Again, no side effects are observed at this dose.