一二三四区视频,亚洲少妇熟女色,日本久热无码视频网,欧美国产日韩大尺度,亚洲a视频,久久少妇一区二区,日韩999无码视频,刺激久久久久久久,啊啊啊啊不要啊在线

返回ChemicalBook首頁(yè)>CAS數(shù)據(jù)庫(kù)列表>14748-94-8

14748-94-8

中文名稱 AMINAFTONE
英文名稱 1,4-dihydroxy-3-methyl-2-naphthyl 4-aminobenzoate
CAS 14748-94-8
分子式 C18H15NO4
分子量 309.316
MOL 文件 14748-94-8.mol
14748-94-8 結(jié)構(gòu)式 14748-94-8 結(jié)構(gòu)式

基本信息

中文別名
化合物 T14219
1,4-二羥基-3-甲基-2-萘基4-氨基苯甲酸酯
英文別名
Menatriol
Capilarema
Aminaftone
Capillarema
Aminaphthone
Einecs 238-809-8
1,4-dihydroxy-3-methyl-2-naphthyl 4-aminobenzoate
3-Methyl-1,2,4-naphthalenetriol-2-(4-aminobenzoate)
1,2,4-Naphthalenetriol, 3-methyl-, 2-(4-aminobenzoate)
4-Aminobenzoic acid 1,4-dihydroxy-3-methylnaphthalen-2-yl ester

物理化學(xué)性質(zhì)

沸點(diǎn)617.1±55.0 °C(Predicted)
密度1.390±0.06 g/cm3(Predicted)
儲(chǔ)存條件-20°C儲(chǔ)存
溶解度溶于二甲基亞砜
酸度系數(shù)(pKa)8.00±0.50(Predicted)

安全數(shù)據(jù)

危險(xiǎn)性符號(hào)(GHS)環(huán)境危害 (GHS09)
GHS09
警示詞警告
危險(xiǎn)性描述H400
防范說明P273-P391-P501

常見問題列表

生物活性
Aminaftone 是 4-氨基苯甲酸的衍生物,通過干擾 pre-pro-ET-1 基因轉(zhuǎn)錄,而下調(diào)內(nèi)皮素-1 (ET-1) 產(chǎn)生。
靶點(diǎn)

endothelin-1 (ET-1)

體外研究

Aminaftone inhibits Endothelin-1 (ET-1) production in cell cultures by interfering with transcription of the pre-pro-endothelin-1 (PPET-1) gene. Incubation with IL-1beta increases concentrations of ET-1 and PPET-1 relative gene expression. Incubation with Aminaftone significantly reduces production of ET-1 in a concentration-dependent manner. A strong direct correlation is found between ET-1 concentrations and PPET-1 relative gene expression, but Aminaftone does not influence endothelin-converting enzyme (ECE) activity.

體內(nèi)研究

The rats are randomly assigned to the following experimental groups: Control; Monocrotaline; Aminaftone 30 mg/kg/day; Aminaftone 150 mg/kg/day. After 5 weeks, mortality is significantly lower in the animals treated with Aminaftone at both doses compared to Monocrotaline alone. Aminaftone reduces plasma concentration of ET-1 and seems to reduce right heart hypertrophy and the wall thickness of the pulmonary arteries at the highest dose. At the end of the experiment, no rats die in the control and Aminaftone 150 groups, while mortality is 38% in the Monocrotaline group and 13% in the Aminaftone 30 group. Overall, Aminaftone treated rats have a significantly lower mortality compared to rats in the Monocrotaline group (P=0.044).

"14748-94-8" 相關(guān)產(chǎn)品信息
手游| 邵武市| 德州市| 阳信县| 绥化市| 麻栗坡县| 烟台市| 渭源县| 德安县| 攀枝花市| 通山县| 麻江县| 东辽县| 金华市| 日照市| 志丹县| 全南县| 威远县| 合川市| 观塘区| 西宁市| 夹江县| 阳信县| 密山市| 中超| 仪陇县| 德江县| 康乐县| 富民县| 习水县| 玉环县| 邯郸县| 赫章县| 和林格尔县| 昭觉县| 南昌县| 丘北县| 根河市| 鹰潭市| 沙雅县| 额尔古纳市|