147782-19-2
147782-19-2 結(jié)構(gòu)式
基本信息
2-(2,3-dicarboxycyclopropyl)glycine
(2S,2'R,3'R)-2-(2',3'-DICARBOXYCYCLOPROPYL)GLYCINE
1,2-Cyclopropanedicarboxylic acid, 3-[(S)-aminocarboxymethyl]-, (1R,2R)-
物理化學(xué)性質(zhì)
常見問題列表
|
mGluR2R 0.35 μM (EC 50 ) |
mGluR3R 0.09 μM (EC 50 ) |
mGluR1R 389 μM (IC 50 ) |
mGluR5 630 μM (IC 50 ) |
mGluR4R 22.5 μM (IC 50 ) |
mGluR6 39.6 μM (IC 50 ) |
mGluR7 40.1 μM (IC 50 ) |
mGluR8 32 μM (IC 50 ) |
DCG-IV is also an NMDA receptor agonist in the rat cortical slice.
DCG-IV (1-10 mg/kg; i.p.) depresses the phencyclidine (PCP)-induced hyperlocomotion.
| Animal Model: | Male ICR mice weighing about 40 g (PCP-induced locomotor activity) |
| Dosage: | 10, 5, or 1 mg/kg |
| Administration: | I.p. |
| Result: | Reduced spontaneous activities of the animals at 10 or 5 mg/kg. |