148451-96-1

中文名稱 L732138

英文名稱 AC-TRP-3,5-BIS(TRIFLUOROMETHYL)BENZYL ESTER

CAS 148451-96-1

分子式 C22H18F6N2O3

分子量 472.38

MOL 文件 148451-96-1.mol

更新日期 2026/05/25 13:08:19

148451-96-1 結(jié)構(gòu)式

基本信息物理化學性質(zhì) 安全數(shù)據(jù) 圖譜信息 L732138價格(試劑級) 常見問題列表

基本信息

中文別名

N-乙酰基-L-色氨酸-3,5-雙(三氟甲基)苯酯

英文別名

L732138
L-732,138
AC-TRP-3,5-BIS(TRIFLUOROMETHYL)BENZYL ESTER
N-acetyl-L-tryptophan 3,5-bis*(trifluoromethyl)be
3,5-bis(trifluoromethyl)benzyl N-acetyltryptophan
N-ACETYL-L-TRYPTOPHAN 3,5-BIS(TRIFLUOROM ETHYL)BENZ
N-ACETYL-L-TRYPTOPHAN 3,5-BIS(TRIFLUOROMETHYL)-BENZYL ESTER
N-Acetyl-L-tryptophan 3,5-bis(trifluoromethyl)benzyl ester,L-732,138
L-Tryptophan, N-acetyl-, [3,5-bis(trifluoromethyl)phenyl]methyl ester
N-Acetyl-L-tryptophan 3,5-bis(trifluoromethyl)benzyl ester >=99% (TLC), powder

物理化學性質(zhì)

熔點147-148 °C(lit.)

沸點554.1±50.0 °C(Predicted)

密度1.396±0.06 g/cm3(Predicted)

儲存條件Sealed in dry,Store in freezer, under -20°C

溶解度Soluble to 100 mM in ethanol and to 100 mM in DMSO

酸度系數(shù)(pKa)14.63±0.46(Predicted)

形態(tài)powder

顏色White to off-white

安全數(shù)據(jù)

危險性符號(GHS) 有害 (GHS07)

GHS07

警示詞警告

危險性描述H302-H315-H319-H335

防范說明P261-P280-P301+P312-P302+P352-P305+P351+P338

WGK Germany3

圖譜信息

L732138(148451-96-1)核磁圖(¹HNMR)

L732138價格(試劑級)

報價日期	產(chǎn)品編號	產(chǎn)品名稱	CAS號	包裝	價格
2026/06/05	HY-101249	L732138 L-732138	148451-96-1	5mg	677元
2026/06/05	HY-101249	L732138 L-732138	148451-96-1	10mM * 1mLin DMSO	704元
2026/06/05	HY-101249	L-732138	148451-96-1	10 mg	1050元

常見問題列表

生物活性

L-732138 (L-732,138) 是一種有效的、選擇性的 neurokinin-1 (NK-1) receptor/substance P (SP) receptor 的競爭性拮抗劑。L-732138 可在CHO細胞中抑制125I-SP與穩(wěn)定表達的人類NK-1受體的結(jié)合，其IC50值為2.3 nM。

靶點

Target	Value
NK-1 receptor (in CHO cells)	2.3 nM

體外研究

L-732138 (0 -100 μM; first doubling time; COLO 858, MEL HO and COLO 679 cells) treatment results in a concentration-dependent cytotoxicity. L-732138 inhibits cell growth with IC ₅₀ of 44.6 μM for COLO 858 cells, 76.3 μM for MEL HO cells and 64.2 μM for COLO 679 cells. L-732138 blocks substance P (SP) mitogen stimulation.
L-732,138 treatment results in a large number of apoptotic cells were found in COLO 858, MEL HO and COLO 679 melanoma cell lines. In DAPI-stained cultures, at IC ₅₀ concentration of 43.6% apoptotic cells for the three melanoma cell lines, whereas at IC ₁₀₀ concentration of 51.4 % apoptotic cells.

Cell Proliferation Assay

Cell Line:	COLO 858, MEL HO and COLO 679 cells
Concentration:	0 μM, 20 μM, 40 μM, 60 μM, 80 μM, 100 μM
Incubation Time:	First doubling time
Result:	Resulted in a concentration-dependent cytotoxicity.

體內(nèi)研究

L-732138 (10 ^-4 -10 ^-2 mol/kg; intravenous injection; for 15 minutes; male Dunkin-Hartley guinea-pigs) treatment abolishes vagally-induced plasma exudation and significantly inhibits the enhancement by LPS. The LPS-enhanced vagally-induced plasma exudation is not completely inhibited by either L-732138 or SOD pretreatment alone, but is blocked by the combination of both pretreatments.

Animal Model:	Male Dunkin-Hartley guinea-pigs (350-500 g) injected with lipopolysaccharide (LPS)
Dosage:	10 ^-4 mol/kg , 10 ^-3 mol/kg and 10 ^-2 mol/kg
Administration:	Intravenous injection; for 15 minutes
Result:	Abolished the vagally-induced plasma leakage in tracheobronchial tissues, and dose-dependently inhibited the LPS enhanced vagally-induced plasma exudation in traceobronchial tissues.