150493-34-8
150493-34-8 結(jié)構(gòu)式
基本信息
1-[(4-氯苯基)甲基]-5-(三氟甲基)苯并咪唑-2-胺
1-[(4-氯苯基)甲基]-5-(三氟甲基)苯并咪唑-2-胺, >98%
NS638, >98%
NS-638
NS 638
2-amino-1-(4-chlorobenzyl)-5-trifluoromethylbenzimidazole
1-[(4-Chlorophenyl)Methyl]-5-(Trifluoromethyl)Benzimidazol-2-Amine
1H-Benzimidazol-2-amine,1-[(4-chlorophenyl)methyl]-5-(trifluoromethyl)-
物理化學(xué)性質(zhì)
| 報價日期 | 產(chǎn)品編號 | 產(chǎn)品名稱 | CAS號 | 包裝 | 價格 |
| 2025/12/22 | HY-101428 | 150493-34-8 NS-638 | 150493-34-8 | 2mg | 500元 |
| 2025/12/22 | HY-101428 | 150493-34-8 NS-638 | 150493-34-8 | 10mM * 1mLin DMSO | 896元 |
| 2025/12/22 | HY-101428 | 150493-34-8 NS-638 | 150493-34-8 | 5mg | 940元 |
常見問題列表
IC50: 3.4 μM (K + -stimulated intracellular Ca 2+ -elevation)
NS-638 dose dependently inhibits K + -stimulated [45 Ca 2+ ]-uptake in chick cortical synaptosomes and 2-amino-3-(3-hydroxy-5-methylisoxazol-4-yl)propionic acid (AMPA)- stimulated [ 3 H]GABA-release from cultured cortical neurons with IC 50 values of 2.3 and 4.3 μM, respectively. K + -stimulated intracellular Ca 2+ -elevation in cultured cerebellar granule cells is equipotently blocked with an IC 50 value of 3.4 μM. At this concentration no effect on Ca 2+ -induced contractions in K + -depolarized guinea pig taenia coli is observed. NS-638 reversibly blocks N- and L-type Ca 2+ -channels in cultured chick dorsal root ganglion cells in the concentration range of 1-30 μM.
In the mouse middle cerebral artery occlusion model, NS-638 administered i.p. (50 mg kg-1) at 1 h and 6 h post-ischemia, and once a day for the next two days, results in a 48% reduction in total infarct volume. It does not show protection against ischemic neuronal damage in the gerbil model of bilateral carotid artery occlusion.