151358-47-3
151358-47-3 結(jié)構(gòu)式
基本信息
4(二(1H-吲哚-3-基)甲基)苯酚
DIM-C-pPhOH
DIM-C-pPhOH(CDIM8)
4-(di(1H-indol-3-yl)Methyl)phenol
4-[bis(1H-indol-3-yl)methyl]phenol
Phenol, 4-(di-1H-indol-3-ylmethyl)-
1,1-Bis(3'-indolyl)-1-(p-hydroxyphenyl)methane
物理化學(xué)性質(zhì)
制備方法
120-72-9
123-08-0
151358-47-3
通用方法：將BiVO4納米顆粒（BiVO4-NPs，30 mg）加入至含有吲哚或2-甲基吲哚（2 mmol）與醛類化合物（1 mmol）的混合物中。在無溶劑條件下，將反應(yīng)混合物于80℃攪拌反應(yīng)適當(dāng)時間。反應(yīng)進(jìn)程通過薄層色譜（TLC）監(jiān)測。反應(yīng)完成后，用30 mL熱乙醇稀釋反應(yīng)混合物，通過過濾回收催化劑，并用乙醇（5 mL）洗滌。減壓蒸發(fā)溶劑，剩余固體通過乙醇/水（95:5，v/v）混合溶劑重結(jié)晶，得到純產(chǎn)物4-(二(1H-吲哚-3-基)甲基)苯酚。所有產(chǎn)物的光譜及物理數(shù)據(jù)與文獻(xiàn)報道一致，并與按先前報道方法制備的樣品相符。
參考文獻(xiàn)：
[1] Tetrahedron Letters, 2003, vol. 44, # 9, p. 1959 - 1961
[2] Journal of Chemical Research, 2004, # 1, p. 34 - 36
[3] Monatshefte fur Chemie, 2004, vol. 135, # 10, p. 1265 - 1273
[4] RSC Advances, 2016, vol. 6, # 96, p. 93546 - 93550
[5] Synthetic Communications, 2004, vol. 34, # 3, p. 487 - 492
| 報價日期 | 產(chǎn)品編號 | 產(chǎn)品名稱 | CAS號 | 包裝 | 價格 |
| 2026/03/03 | S6799 | 4(二(1H-吲哚-3-基)甲基)苯酚 DIM-C-pPhOH | 151358-47-3 | 5mg | 770.25元 |
| 2026/03/03 | S6799 | 4(二(1H-吲哚-3-基)甲基)苯酚 DIM-C-pPhOH | 151358-47-3 | 10mM (1mL in DMSO) | 958.23元 |
| 2026/03/03 | S6799 | 4(二(1H-吲哚-3-基)甲基)苯酚 DIM-C-pPhOH | 151358-47-3 | 25mg | 1975.48元 |
常見問題列表
| Target | Value |
|
Nur77
(786-O cells based assay) | 13.0 μM |
|
Nur77
(ACHN cells based assay) | 13.6 μM |
DIM-C-pPhOH (7.5-20 μM; 24 hours; ACHN and 786-O cells) treatment significantly decreases cell proliferation.
DIM-C-pPhOH (20 μM; 24 hours; ACHN and 786-O cells) treatment induces Annexin V staining in ACHN and 786-O cells, confirming that DIM-C-pPhOH induce apoptosis, and also induces cleavage of caspases 7 and 8.
DIM-C-pPhOH (15-20 μM; 24 hours; ACHN and 786-O cells) treatment inhibits NR4A1-regulated expression of survivin, bcl-2 and EGFR in ACHN and 786-O cells. And also induces sestrin 2, activates AMPKα and inhibits activation of mTOR and downstream kinases.
DIM-C-pPhOH decreases expression of β1-integrin protein and mRNA and β1-integrin-dependent responses in MCF7, MDA-MB-231, and SKBR3 cells and also inhibits migration of the latter two cell lines.
Cell Proliferation Assay
| Cell Line: | ACHN and 786-O cells |
| Concentration: | 7.5 μM, 15 μM, 20 μM |
| Incubation Time: | 24 hours |
| Result: | Significantly decreased cell proliferation. |
Apoptosis Analysis
| Cell Line: | ACHN and 786-O cells |
| Concentration: | 20 μM |
| Incubation Time: | 24 hours |
| Result: | Induced apoptosis in ACHN and 786-O cells. |
Western Blot Analysis
| Cell Line: | ACHN and 786-O cells |
| Concentration: | 15 μM, 20 μM |
| Incubation Time: | 24 hours |
| Result: | Inhibited NR4A1-regulated expression of survivin, bcl-2 and EGFR in ACHN and 786-O cells. And also induced sestrin 2, activated AMPKα and inhibited activation of mTOR and downstream kinases. |
DIM-C-pPhOH (30 mg/kg; oral gavage; daily; for 50 days; male athymic nude mice) treatment results in a significant inhibition of tumor growth.
| Animal Model: | Male athymic nude mice (aged 6-7 weeks) injected with ACHN cells |
| Dosage: | 30 mg/kg/day |
| Administration: | Oral gavage; daily; for 50 days |
| Result: | Resulted in a significant inhibition of tumor growth. |