1568-80-5
1568-80-5 結(jié)構(gòu)式
基本信息
螺二茚滿
3,3,3',3'-四甲基螺環(huán)二酚
3,3,3',3'-四甲基-1,1'-螺BI(茚滿)-6,6'-二醇
3,3,3',3'-四甲基-2,2',3,3'-四氫-1,1'-螺二[茚滿]-6,6'-二醇
SPIROBIINDANE
-tetrahydro-1,1'
-tetramethyl-2,2'
-spirobi[indene]-6,6'
HIV-1 integrase inhibitor 8
3,3,3',3'-Tetramethyl-1,1'-spirobi[indan]-6,6'-diol
tetrahydrotetramethyl-1,1'-spirobi-1H-indene-6,6'-diol
6,6'-Dihydroxy-3,3,3',3'-tetramethyl-1,1'-spirobiindan
6,6'-Dihydroxy-3,3,3',3'-tetramethyl-1,1'-spirobiindane
物理化學(xué)性質(zhì)
安全數(shù)據(jù)
制備方法
80-05-7
1568-80-5
向反應(yīng)燒瓶中加入100g雙酚A和500mL甲磺酸，攪拌至完全溶解，形成暗紅色溶液。在室溫下持續(xù)攪拌反應(yīng)96小時(shí)。反應(yīng)完成后，將反應(yīng)液緩慢倒入600mL冰水中，冷卻至室溫后進(jìn)行抽濾。收集的固體用去離子水充分洗滌。將洗滌后的固體在回流條件下溶于乙醇和50℃的熱水中。隨后，向溶液中滴加甲醇直至無(wú)固體析出，立即進(jìn)行熱過(guò)濾。濾餅用熱水洗滌數(shù)次，最后將產(chǎn)物在適宜條件下干燥，得到近白色絮狀固體45g，即3,3,3',3'-四甲基-2,2',3,3'-四氫-1,1'-螺二[茚滿]-6,6'-二醇（MSPINOL），產(chǎn)率超過(guò)99%。
參考文獻(xiàn)：
[1] Patent: CN108659041, 2018, A. Location in patent: Paragraph 0056; 0057; 0058; 0059
[2] Organic Letters, 2004, vol. 6, # 14, p. 2341 - 2343
[3] Patent: JP6167868, 2017, B2. Location in patent: Paragraph 0285; 0286; 0292; 0300; 0312; 0317; 0322; 0330
[4] Patent: WO2005/61425, 2005, A1. Location in patent: Page/Page column 18
[5] Patent: US2006/20150, 2006, A1. Location in patent: Page/Page column 5
| 報(bào)價(jià)日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱 | CAS號(hào) | 包裝 | 價(jià)格 |
| 2026/06/05 | HY-107485 | 3,3,3',3'-四甲基-1,1'-螺BI(茚滿)-6,6'-二醇 HIV-1 integrase inhibitor 8 | 1568-80-5 | 50mg | 300元 |
| 2026/06/05 | HY-107485 | 3,3,3',3'-四甲基-1,1'-螺BI(茚滿)-6,6'-二醇 HIV-1 integrase inhibitor 8 | 1568-80-5 | 10 mM * 1 mLin DMSO | 330元 |
| 2026/06/05 | HY-107485 | 3,3,3',3'-四甲基-1,1'-螺BI(茚滿)-6,6'-二醇 HIV-1 integrase inhibitor 8 | 1568-80-5 | 100mg | 500元 |
常見問(wèn)題列表
HIV-1 integrase inhibitor 8 is against 3′-processing (TC) and strand-transfer (ST) activities in the presence of Mn 2+ as the cationic cofactor by gel assay with IC 50 values of 275 μM and 200 μM, respectively. It inhibits the strand-transfer (ST) activity with an IC 50 value of 200 μM.The DNA relaxation activity of MCV topoisomerase is monitored by gel electrophoresis, while DNA cleavage and religation activities were monitored using a microtiter assay. HIV-1 integrase inhibitor 8 inhibits MCV topoisomerase and DNA religation with IC 50 values of 500 μM and 200 μM, respectively. This result demonstrates that compound 8 is inactive against topoisomerase in both assays. HIV-1 integrase inhibitor 8 induces cell cytotoxicity and yields a LD 50 (dose at which the signal is reduced 50% due to cell death) of 20 μM in HeLa cells.