158800-83-0
中文名稱
七葉皂苷D
英文名稱
ESCIN IIB
CAS
158800-83-0
分子式
C54H84O23
分子量
1101.23
MOL 文件
158800-83-0.mol
更新日期
2026/03/20 17:39:03
158800-83-0 結(jié)構(gòu)式
基本信息
中文別名
七葉皂苷D七葉皂苷 IIB
英文別名
ESCIN IIBAESCIN IIB
06035642G6
b-D-Glucopyranosiduronic acid, (3b,4b,16a,21b,22a)-22-(acetyloxy)-16,23,28-trihydroxy-21-[[(2Z)-2-methyl-1-oxo-2-butenyl]oxy]olean-12-en-3-ylO-b-D-glucopyranosyl-(14)-O-[b-D-xylopyranosyl-(12)]-
β-D-Glucopyranosiduronic acid, (3β,4β,16α,21β,22α)-22-(acetyloxy)-16,23,28-trihydroxy-21-[[(2Z)-2-methyl-1-oxo-2-butenyl]oxy]olean-12-en-3-yl O-β-D-glucopyranosyl-(1→4)-O-[β-D-xylopyranosyl-(1→2)]-
所屬類別
生物化工：植物提取物物理化學(xué)性質(zhì)
沸點(diǎn)1111.9±65.0 °C(Predicted)
密度1.45±0.1 g/cm3 (20 ºC 760 Torr)
酸度系數(shù)(pKa)2.63±0.70(Predicted)
常見問題列表
生物活性
Escin IIb 是從七葉樹種子七葉樹中分離出來的，對(duì)動(dòng)物急性炎癥有積極作用。Escin IIb 對(duì)乙醇誘導(dǎo)的胃粘膜損傷有明顯的保護(hù)作用。體內(nèi)研究
Escins Ia, Ib, IIa, and IIb (50-200 mg/kg) inhibit the increase of vascular permeability induced by both acetic acid in mice and histamine in rats. Escins Ib, IIa, and IIb (50-200 mg/kg) also inhibit that induced by serotonin in rats, but escin Ia didn't. Escins Ia, Ib, IIa, and IIb (200 mg/kg) inhibit the hind paw edema induced by carrageenin at the first phase in rats. Escin Ia (200 mg/kg) and escins Ib, IIa, and IIb (50-200 mg/kg) inhibit the scratching behavior induced by compound 48/80 in mice, but escin Ia was weakest.
Escin IIb (10-50 mg/kg; p.o.) potently inhibits ethanol-induced gastric mucosal lesions.
| Animal Model: | Male Sprague–Dawley rats (Ethanol-induced gastric mucosal lesions in rats) |
| Dosage: | P.o. |
| Administration: | 10-50 mg/kg |
| Result: | Showed a potent protective effect against ethanol-induced gastric lesions in rats. |