159138-80-4
159138-80-4 結(jié)構(gòu)式
基本信息
N-(氨基亞氨基甲基)-4-(1-甲基乙基)-3-(甲磺酰基)苯甲酰胺
CARIPORIDE
Cariporide (HOE-642)
N-(diaminomethylene)-4-isopropyl-3-mesyl-benzamide
N-(Aminoiminomethyl)-4-(1-methylethyl)-3-(methylsulfonyl)benzamide
N-[bis(azanyl)methylidene]-3-methylsulfonyl-4-propan-2-yl-benzamide
BenzaMide,N-(aMinoiMinoMethyl)-4-(1-Methylethyl)-3-(Methylsulfonyl)-
物理化學(xué)性質(zhì)
安全數(shù)據(jù)
| 報(bào)價(jià)日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱 | CAS號(hào) | 包裝 | 價(jià)格 |
| 2026/06/05 | HY-19693R | 卡立泊來(lái)德 Cariporide (Standard) | 159138-80-4 | 5 mg | 1375元 |
| 2026/06/05 | HY-19693 | 卡立泊來(lái)德 Cariporide | 159138-80-4 | 1 mg | 250元 |
| 2026/06/05 | HY-19693R | 卡立泊來(lái)德 Cariporide (Standard) | 159138-80-4 | 10 mg | 2304元 |
常見問(wèn)題列表
| Target | Value |
|
NHE1
(CHO-K1 cells) | 30 nM |
Cariporide significantly suppresses markers of cell death, such as TUNEL positivity and caspase-3 cleavage, at 8 or 16 hours. Cariporide remarkably suppresses cytosolic Na + and Ca 2+ accumulation. Cariporide prevents mitochondrial membrane potential loss induced by H 2+ O 2+ . Cariporide (HOE-642) ameliorates myocardial ischemia/reperfusion injury, by the well-established reduction of cytosolic Ca 2+ in cardiac myocytes through inhibition of Na + /H + exchange. Cariporide (HOE-642), has inhibitory effects on the degranulation of human platelets, the formation of platelet–leukocyte-aggregates, and the activation of the GPIIb/IIIa receptor (PAC-1).
Intravenous administration of cariporide significantly decreases brain Na + uptake and reduces cerebral edema, brain swelling, and infarct volume.