163655-37-6

中文名稱 CS-2885

英文名稱 MAZ51

CAS 163655-37-6

分子式 C21H18N2O

分子量 314.38

MOL 文件 163655-37-6.mol

更新日期 2026/08/06 16:39:17

163655-37-6 結(jié)構(gòu)式

基本信息物理化學(xué)性質(zhì) 安全數(shù)據(jù) 圖譜信息 CS-2885價格(試劑級) 常見問題列表

基本信息

中文別名

化合物MAZ51
3-((4-(二甲基氨基)萘-1-基)亞甲基)吲哚啉-2-酮

英文別名

MAZ51
CS-2885
MAZ51
MAZ-51
MAZ 51
VEGFR3 Kinase Inhibitor, MAZ
3-(4-DIMETHYLAMINO-NAPHTHALEN-1-YLMETHYLENE)-1,3-DIHYDRO-INDOL-2-ONE
(3E)-3-[[4-(dimethylamino)naphthalen-1-yl]methylidene]-1H-indol-2-one
(3E)-3-{[4-(Dimethylamino)-1-naphthyl]methylene}-1,3-dihydro-2H-indol-2-one
2H-Indol-2-one, 3-[[4-(dimethylamino)-1-naphthalenyl]methylene]-1,3-dihydro-

物理化學(xué)性質(zhì)

儲存條件2-8°C

溶解度DMSO: 11 mg/mL

形態(tài)solid

顏色orange

InChI1S/C21H18N2O/c1-23(2)20-12-11-14(15-7-3-4-9-17(15)20)13-18-16-8-5-6-10-19(16)22-21(18)24/h3-13H,1-2H3,(H,22,24)

InChIKeyVFCXONOPGCDDBQ-UHFFFAOYSA-N

SMILESN1c2c(cccc2)C(=Cc3c4c(c(cc3)N(C)C)cccc4)C1=O

安全數(shù)據(jù)

危險性符號(GHS) 有害 (GHS07)

GHS07

警示詞警告

危險性描述H302-H315-H319-H335

防范說明P261-P280-P301+P312-P302+P352-P305+P351+P338

危險品標(biāo)志Xn,N

危險類別碼22-37/38-41-51/53

安全說明26-39-61

危險品運(yùn)輸編號UN 3077 9/PG 3

WGK GermanyWGK 3

存儲類別11 - Combustible Solids

圖譜信息

CS-2885(163655-37-6)核磁圖(¹HNMR)

CS-2885價格(試劑級)

報價日期	產(chǎn)品編號	產(chǎn)品名稱	CAS號	包裝	價格
2026/07/06	S0765	CS-2885 MAZ51	163655-37-6	5mg	1170.08元
2026/07/06	S0765	MAZ51	163655-37-6	10mM (1mL in DMSO)	1570元
2026/07/06	S0765	CS-2885 MAZ51	163655-37-6	25mg	3570.23元

常見問題列表

生物活性

MAZ51 是一種選擇性的 vascular endothelial growth factor receptor (VEGFR)-3 (Flt-4) tyrosine kinase 的有效抑制劑。MAZ51 通過 Akt/GSK3β 的磷酸化和 RhoA 的激活來誘導(dǎo)神經(jīng)膠質(zhì)瘤細(xì)胞的細(xì)胞圓縮和G2/M細(xì)胞周期停滯。 MAZ51 可抑制多種非VEGFR-3表達(dá)腫瘤細(xì)胞的增殖并誘導(dǎo)其凋亡。

靶點(diǎn)

Target	Value
VEGFR-3 ()
Akt ()
GSK3β ()
RhoA ()

體外研究

MAZ51 (2.5-10 μM; 24 hours) blocks proliferation and induces apoptosis in a wide variety of tumor cells.
MAZ51 (0.5-50 μM; 25 minutes) has no effect on ligand-induced autophosphorylation of EGFR, IGF-1R and PDGFRβ in A431 cells, HEK-293 cells, and PAE cells, respectively.

Cell Proliferation Assay

Cell Line:	MT450, 1AS, ASM, G, AT6.1, MTLN3, MTLY, NM-081 cells
Concentration:	2.5, 10 μM
Incubation Time:	24 hours
Result:	Induced apoptosis in a wide variety of tumor cells.

Apoptosis Analysis

Cell Line:	MT450, 1AS, ASM, G, AT6.1, MTLN3, MTLY, NM-081 cells
Concentration:	2.5, 10 μM
Incubation Time:	24 hours
Result:	Blocked proliferation in a wide variety of tumor cells.

體內(nèi)研究

MAZ51 (8 mg/kg; i.p.; daily for 15 day) significantly suppresses the growth of MT450 tumors.

Animal Model:	Wistar Furth rats (bearing MT450 cells)
Dosage:	8 mg/kg
Administration:	Intraperitoneal injection; daily for 15 day
Result:	Significantly suppressed the growth of MT450 tumors.