166815-96-9
166815-96-9 結(jié)構(gòu)式
基本信息
1-BOC-4-對(duì)甲苯磺酰氧基哌啶
1-BOC-4-(對(duì)二甲苯磺酸基)哌啶
1-BOC-4-(P-甲苯磺酰氧甲基)哌啶
N-BOC-4-(4-甲基苯磺酸甲基)哌啶
N-BOC-4-(4-甲苯磺酰氧基甲基)哌啶
N-BOC-4-(4-甲基苯磺酰氧甲基)哌啶
1-BOC-4-[(對(duì)甲苯磺?；趸?甲基]哌啶
1-BOC-4-(O-對(duì)甲苯磺?；?羥甲基)哌啶
1-N-BOC-4-(4-甲基苯磺酰氧甲基)哌啶
tert-Butyl 4-((tosyloxy)
1-Boc-4-(tosyloxyMethyl)piperidine
N-Boc-4-(4-toluenesulfonyloxymethyl)piperidine
1-N-bOC-4-(4-TOLUENESULFONYLOXYMETHYL)PIPERIDINE
1-Boc-4-(p-toluenesulfonyloxymethyl)piperidine,96%
1-Boc-4-(p-toluenesulfonyloxyMethyl)piperidine, 96%
N-tert-Butoxycarbonyl-4-(4-toluenesulfonyloxymethyl)
N-(tert-Butoxycarbonyl)-4-(tosyloxymethyl)piperidine
1-(tert-Butoxycarbonyl)-4-(tosyloxymethyl)piperidine
物理化學(xué)性質(zhì)
制備方法
98-59-9
123855-51-6
166815-96-9
實(shí)施例1A 4-((甲苯磺酰氧基)甲基)哌啶-1-羧酸叔丁酯的合成：在氮?dú)獗Ｗo(hù)下，將N-BOC-4-哌啶甲醇（10g，46.5mmol）和三乙胺（5.64g，55.8mmol）溶解于二氯甲烷（100mL）中，冷卻至0℃。隨后，向該溶液中緩慢加入對(duì)甲苯磺酰氯（9.73g，51.2mmol）和4-二甲氨基吡啶（1.13g，9.3mmol）。反應(yīng)混合物在17℃下攪拌2小時(shí)。反應(yīng)完成后，加入水（100mL）淬滅反應(yīng)。用二氯甲烷（100mL×2）萃取水層。合并有機(jī)層，用無(wú)水硫酸鈉干燥，過(guò)濾后減壓濃縮，得到粗產(chǎn)物。通過(guò)柱色譜純化，得到1-N-Boc-4-(4-甲基苯磺酰氧甲基)哌啶（17g，99%收率），為白色固體。LCMS（ESI）m/z：370（M + 1）。
參考文獻(xiàn)：
[1] Patent: US2017/29430, 2017, A1. Location in patent: Paragraph 0255
[2] Patent: CN105315267, 2016, A. Location in patent: Paragraph 0033; 0049
[3] Patent: WO2008/42282, 2008, A2. Location in patent: Page/Page column 107-108; 168-169; 210-211
[4] Patent: WO2012/168349, 2012, A1. Location in patent: Page/Page column 37
[5] Patent: US2013/34504, 2013, A1. Location in patent: Paragraph 0147; 0148; 0149
| 報(bào)價(jià)日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱 | CAS號(hào) | 包裝 | 價(jià)格 |
| 2025/12/22 | B4759 | 1-叔丁氧羰基-4-[(對(duì)二甲苯磺酸基)甲基]哌啶 1-(tert-Butoxycarbonyl)-4-[(p-toluenesulfonyloxy)methyl]piperidine | 166815-96-9 | 5g | 240元 |
| 2025/12/22 | XW0216681596905 | 1-BOC-4-(P-甲苯磺酰氧甲基)哌啶 | 166815-96-9 | 100G | 697元 |
| 2025/12/22 | XW0216681596904 | 1-BOC-4-(P-甲苯磺酰氧甲基)哌啶 | 166815-96-9 | 25G | 239元 |