174634-09-4

中文名稱 6-[[2-(二甲基氨基)乙基]氨基]-3-羥基-7H-茚并[2,1-C]喹啉-7-酮二鹽酸鹽

英文名稱 TAS 103

CAS 174634-09-4

分子式 C20H21Cl2N3O2

分子量 406.306

MOL 文件 174634-09-4.mol

更新日期 2024/06/17 17:25:40

174634-09-4 結(jié)構(gòu)式

基本信息物理化學(xué)性質(zhì) 安全數(shù)據(jù) 圖譜信息 6-[[2-(二甲基氨基)乙基]氨基]-3-羥基-7H-茚并[2,1-C]喹啉-7-酮二鹽酸鹽價格(試劑級) 常見問題列表

基本信息

中文別名

TAS-103雙鹽酸鹽
TAS-103(BMS-247615)鹽
拓?fù)洚悩?gòu)酶I和II抑制劑(TAS-103雙鹽酸鹽)
6-[[2-(二甲基氨基)乙基]氨基]-3-羥基-7H-茚并[2,1-C]喹啉-7-酮二鹽酸鹽

英文別名

CS-1342
TAS-103(2HCl)
BMS-247615-2HCl
TAS-103(BMS-247615)
TAS 103 (hydrochloride)
BMS247615 dihydrochloride
BMS-247615 dihydrochloride
BMS 247615 dihydrochloride
TAS-103 (dihydrochloride)
TAS 103 dihydrochloride, BMS 247615 dihydrochloride

所屬類別

生物化工：激動劑抑制劑

物理化學(xué)性質(zhì)

儲存條件Inert atmosphere,2-8°C

溶解度PBS (pH 7.2):1.0(Max Conc. mg/mL);2.46(Max Conc. mM)

形態(tài)結(jié)晶固體

顏色Brown to orange

安全數(shù)據(jù)

危險性符號(GHS) 有害 (GHS07)

GHS07

警示詞警告

危險性描述H302-H315-H319-H335

防范說明P261-P305+P351+P338

圖譜信息

6-[[2-(二甲基氨基)乙基]氨基]-3-羥基-7H-茚并[2,1-C]喹啉-7-酮二鹽酸鹽(174634-09-4)核磁圖(¹HNMR)

6-[[2-(二甲基氨基)乙基]氨基]-3-羥基-7H-茚并[2,1-C]喹啉-7-酮二鹽酸鹽價格(試劑級)

報價日期	產(chǎn)品編號	產(chǎn)品名稱	CAS號	包裝	價格
2026/06/05	HY-13758A	6-[[2-(二甲基氨基)乙基]氨基]-3-羥基-7H-茚并[2,1-C]喹啉-7-酮二鹽酸鹽 TAS-103 dihydrochloride	174634-09-4	1 mg	500元
2026/06/05	HY-13758A	6-[[2-(二甲基氨基)乙基]氨基]-3-羥基-7H-茚并[2,1-C]喹啉-7-酮二鹽酸鹽 TAS-103 dihydrochloride	174634-09-4	5mg	1100元
2026/06/05	HY-13758A	6-[[2-(二甲基氨基)乙基]氨基]-3-羥基-7H-茚并[2,1-C]喹啉-7-酮二鹽酸鹽 TAS-103 dihydrochloride	174634-09-4	10mM * 1mLin Water	1210元

常見問題列表

生物活性

TAS-103 dihydrochloride 是一種 DNA 拓?fù)洚悩?gòu)酶 I/II (topoisomerase I/II) 雙重抑制劑，可用于癌癥研究。

靶點(diǎn)

Topoisomerase I

Topoisomerase II

體外研究

TAS-103 is a dual inhibitor of DNA topoisomerase I/II. TAS-103 (0.1-10 μM) is active on CCRF-CEM cells, with an IC ₅₀ value of 5 nM. TAS-103 (0.1 μM) significantly increases levels of topo IIα FITC immunofluorescence in individual CCRF-CEM cells. TAS-103 (0.01-1 μM) is highly cytotoxic to Lewis lung carcinoma (LLC) cells, and Liposomal TAS-103 is almost as active as free TAS-103. TAS-103 inhibits the viability of HeLa cells, with an IC ₅₀ of 40 nM. TAS-103 (10 μM) disrupts signal recognition particle (SRP) complex formation, and induces destabilization of SRP14 and SRP19 and its eventual degradation.

體內(nèi)研究

TAS-103 (30 mg/kg, i.v.) causes significant tumor growth suppression in mice bearing Lewis lung carcinoma (LLC) cells, without obvious body weight loss, and the liposomal TAS-103 is more active than free TAS-103.