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17560-51-9

中文名稱 美托拉宗
英文名稱 Metolazone
CAS 17560-51-9
EINECS 編號(hào) 241-539-3
分子式 C16H16ClN3O3S
MDL 編號(hào) MFCD00069304
分子量 365.83
MOL 文件 17560-51-9.mol
更新日期 2026/04/10 15:26:15
17560-51-9 結(jié)構(gòu)式 17560-51-9 結(jié)構(gòu)式

基本信息

中文別名
7-氯-1,2,3,4-四氫-2-甲基-3-(2-甲基苯基)-4-氧代-6-喹唑磺酰胺
美托拉宗
美托拉腙
甲醋唑胺
英文別名
7-CHLORO-1,2,3,4-TETRAHYDRO-2-METHYL-3-(2-METHYLPHENYL)-4-OXO-6-QUINAZOLINESULFONAMIDE
DIULO
METENIX
METOLAZONE
MYKROX
OLDREN
SR-720-22
1,2,3,4-tetrahydro-7-chloro-2-methyl-4-oxo-3-o-tolyl-6-quinazolinesulfonamid
2-methyl-3-o-tolyl-6-sulfamyl-7-chloro-1,2,3,4-tetrahydro-4-quinazolinone
6-quinazolinesulfonamide,7-chloro-1,2,3,4-tetrahydro-2-methyl-3-(2-methylpheny
6-quinazolinesulfonamide,7-chloro-1,2,3,4-tetrahydro-2-methyl-4-oxo-3-o-toly
7-chloro-1,2,3,4-tetrahydro-2-methyl-3-(2-methylphenyl)-4-oxo-6-quinazolines
7-chloro-1,2,3,4-tetrahydro-2-methyl-3-(2-methylphenyl)-4-oxo-6-quinazolinesul
7-chloro-1,2,3,4-tetrahydro-2-methyl-4-oxo-3-o-tolyl-6-quinazolinesulfonamid
7-chloro-1,2,3,4-tetrahydro-2-methyl-4-oxo-3-tolyl-6-quinazolinesulfonamide
fonamide
l)-4-oxo-
metalozone
microx
s720-22
所屬類別
原料藥:利尿藥

物理化學(xué)性質(zhì)

熔點(diǎn)252-254°C
沸點(diǎn)613.6±65.0 °C(Predicted)
密度1.2895 (rough estimate)
折射率1.6100 (estimate)
儲(chǔ)存條件2-8°C
溶解度二甲基亞砜:>5mg/mL
酸度系數(shù)(pKa)pKa 9.7 (Uncertain)
形態(tài)固體
顏色白色
水溶解性60.3mg/L(25 ºC)
穩(wěn)定性自購買之日起 2 年內(nèi)保持穩(wěn)定。 DMSO 中的溶液可在 -20°C 下干燥保存長達(dá) 2 個(gè)月。
主要應(yīng)用pharmaceutical (small molecule)
InChI1S/C16H16ClN3O3S/c1-9-5-3-4-6-14(9)20-10(2)19-13-8-12(17)15(24(18,22)23)7-11(13)16(20)21/h3-8,10,19H,1-2H3,(H2,18,22,23)
InChIKeyAQCHWTWZEMGIFD-UHFFFAOYSA-N
SMILESCC1Nc2cc(Cl)c(cc2C(=O)N1c3ccccc3C)S(N)(=O)=O
CAS 數(shù)據(jù)庫17560-51-9(CAS DataBase Reference)
NIST化學(xué)物質(zhì)信息Metolazone(17560-51-9)

安全數(shù)據(jù)

危險(xiǎn)性符號(hào)(GHS)有害 (GHS07)
GHS07
警示詞警告
危險(xiǎn)性描述H315-H319-H335
WGK Germany2
RTECS號(hào)VA1700000
海關(guān)編碼2935904000
存儲(chǔ)類別11 - Combustible Solids
毒害物質(zhì)數(shù)據(jù)17560-51-9(Hazardous Substances Data)
毒性LD50 in mice (mg/kg): >5000 orally; >1500 i.p. (Shetty, 1967)

應(yīng)用領(lǐng)域

用途一
利尿藥。

化學(xué)品安全說明書(MSDS)

知名試劑公司產(chǎn)品信息

美托拉宗價(jià)格(試劑級(jí))
報(bào)價(jià)日期產(chǎn)品編號(hào)產(chǎn)品名稱CAS號(hào)包裝價(jià)格
2026/03/03S1610美托拉宗
Metolazone
17560-51-950mg812.06元
2026/03/03S1610美托拉宗
Metolazone
17560-51-91g5487.3元
2025/12/22HY-B0209美托拉宗
Metolazone
17560-51-950mg600元

常見問題列表

生物活性
Metolazone (SR 720-22)是一種利尿劑,主要用于治療充血性心臟衰竭和高血壓。
體外研究

Metolazone (SR-720-22) is a thiazide-like diuretic marketed under the brand names Zytanix from Zydus Cadila, Zaroxolyn, and Mykrox. It is primarily used to treat congestive heart failure and high blood pressure. Metolazone indirectly decreases the amount of water reabsorbed into the bloodstream by the kidney, so that blood volume decreases and urine volume increases. This lowers blood pressure and prevents excess fluid accumulation in heart failure. Metolazone is sometimes used together with loop diuretics such as furosemide or bumetanide, but these highly effective combinations can lead to dehydration and electrolyte abnormalities. Metolazone and the other thiazide diuretics inhibit the function of the sodium-chloride symporter, preventing sodium and chloride, and therefore water too, from leaving the lumen to enter the tubule cell. As a result, water remains in the lumen and is excreted as urine, instead of being reabsorbed into the bloodstream. Since most of the sodium in the lumen has already been reabsorbed by the time the filtrate reaches the distal convoluted tubule, thiazide diuretics have limited effects on water balance and on electrolyte levels. Nevertheless, they can be associated with low sodium levels, volume depletion, and low blood pressure, among other adverse effects.

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