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1758-80-1

中文名稱 L-2,4-二氨基丁酸氫溴酸鹽
英文名稱 L-DAB HBR
CAS 1758-80-1
分子式 C4H10N2O2
MDL 編號 MFCD07368664
分子量 118.13
MOL 文件 1758-80-1.mol
更新日期 2024/08/05 10:18:06
1758-80-1 結構式 1758-80-1 結構式

基本信息

中文別名
L-2,4-二氨基丁酸氫溴酸鹽
英文別名
L-2,4-DIAMINOBUTYRIC ACID HYDROBROMIDE
L-DAB HBR
L-DAB HYDROBROMIDE
L-Dab•
L-2,4-Diaminobutanoate
H-DabHBr
(S)-2,4-Diaminobutyric acid
L-DABA
所屬類別
生物化工:氨基酸鹽

物理化學性質(zhì)

熔點216-218 °C
沸點321.0±32.0 °C(Predicted)
密度1.218±0.06 g/cm3(Predicted)
儲存條件2-8°C(protect from light)
酸度系數(shù)(pKa)2.00±0.10(Predicted)
形態(tài)Powder
顏色White to off-white
CAS 數(shù)據(jù)庫1758-80-1(CAS DataBase Reference)

安全數(shù)據(jù)

危險性符號(GHS)有害 (GHS07)
GHS07
警示詞警告
危險性描述H302-H315-H319-H335
海關編碼2922498590
L-2,4-二氨基丁酸氫溴酸鹽價格(試劑級)
報價日期產(chǎn)品編號產(chǎn)品名稱CAS號包裝價格
2025/12/22HY-101414L-2,4-二氨基丁酸氫溴酸鹽
L-DABA
1758-80-125 mg200元
2025/12/22HY-101414L-2,4-二氨基丁酸氫溴酸鹽
L-DABA
1758-80-150 mg304元
2025/12/22HY-101414L-2,4-二氨基丁酸氫溴酸鹽
L-DABA
1758-80-1100mg500元

常見問題列表

生物活性
L-DABA (L-2,4-Diaminobutyric acid)是GABA轉氨酶的弱抑制劑,IC50 值大于500 μM。在體內(nèi)和體外具有抗腫瘤活性。
靶點

Human Endogenous Metabolite

體外研究

The tumor cells are irreversibly and totally damaged by incubation with 10 mM L-2,4-Diaminobutyric acid for 24 h at 37°C. The cell-destructive effect by L-DABA is probably due to an osmotic lysis induced by the non-saturated intracellular accumulation of L-DABA. The harmful effect of L-DABA could be abolished by concomitant incubation with L-alanine and L-methionine. Kinetic studies indicates that L-DABA is a non-linear, non-competitive inhibitor of GABA transaminase activity. The L-DABA-induced elevation of GABA levels parallels the inhibition of GABA transaminase activity. L-2,4-Diaminobutyric acid, an amino acid analogue, produceS a cytolytic effect with a human glioma cell line, SKMG-1, and normal human fibroblasts. The concentrations of L-DABA necessary to reduce the cell count to 50% of control following a 24-h incubation at 37°C are 12.5 mM for the human fibroblasts and 20 mM for the glioma cell line.

體內(nèi)研究

Treatment with L-DABA results in 43.4% reduction of tumor growth. L-DABA is a more effective inhibitor of GABA transaminase in vivo than in vitro .

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