176708-42-2
中文名稱
N-[2-[[[(E)-3-(4-CHLOROPHENYL)PROP-2-ENYL]-METHYLAMINO]METHYL]PHENYL]-4-METHOXYBENZENESULFONAMIDE
英文名稱
KN92
CAS
176708-42-2
分子式
C24H25ClN2O3S
分子量
456.98
MOL 文件
176708-42-2.mol
更新日期
2026/05/27 08:48:15
176708-42-2 結(jié)構(gòu)式
基本信息
中文別名
化合物 T4530L 英文別名
KN-92KN 92
KN92
N-[2-[[[(E)-3-(4-CHLOROPHENYL)PROP-2-ENYL]-METHYLAMINO]METHYL]PHENYL]-4-METHOXYBENZENESULFONAMIDE
Benzenesulfonamide, N-[2-[[[3-(4-chlorophenyl)-2-propen-1-yl]methylamino]methyl]phenyl]-4-methoxy-
物理化學(xué)性質(zhì)
沸點(diǎn)602.1±65.0 °C(Predicted)
密度1.282±0.06 g/cm3(Predicted)
儲(chǔ)存條件-20°C儲(chǔ)存
溶解度≥ 15.1 mg/mL in DMSO, ≥ 24.2 mg/mL in EtOH with gentle warming
酸度系數(shù)(pKa)8.49±0.10(Predicted)
常見(jiàn)問(wèn)題列表
生物活性
KN-92 是 KN-93 的非活性衍生物，不具有 CaM 激酶抑制活性。KN-92 可作為對(duì)照化合物用于闡明KN-93的拮抗活性。KN-93 可滲透細(xì)胞，可逆和競(jìng)爭(zhēng)性的 CaMKII 抑制劑。體外研究
KN-93 (5-50 μM; 24 hours) inhibits LX-2 cell growth and KN-92 (5-50 μM; 24 hours) is ineffective in blocking cell growth.
The analysis of cell cycle regulator expression reveals that KN-93 rather than KN-92 reduces the expression of p53 and p21.
Cell Viability Assay
| Cell Line: | Human hepatic stellate cells (LX-2) |
| Concentration: | 5-50 μM |
| Incubation Time: | 24 hours |
| Result: | Ineffective in blocking cell growth. |