176957-55-4
176957-55-4 結(jié)構(gòu)式
基本信息
(2E,5E)-2,5-二(2-噻吩基亞甲基)環(huán)戊酮
CCTOO7093
CCT007093
CCT-007093
CCT 007093
CCT007093
2,5-Bis(2-thienylmethylene)-cyclopentanone
(2E,5E)-2,5-Bis(2-thienylmethylene)cyclopentanone
2,5-bis(2-thienylMethylene)-, (E,E)-Cyclopentanone
Cyclopentanone, 2,5-bis(2-thienylMethylene)-, (E,E)-
(2E,5E)-2,5-Bis(thiophen-2-ylmethylene)cyclopentanone
Cyclopentanone, 2,5-bis(2-thienylmethylene)-, (2E,5E)-
物理化學(xué)性質(zhì)
安全數(shù)據(jù)
Skin Irrit. 2
STOT SE 3
常見(jiàn)問(wèn)題列表
環(huán)戊酮曼尼希堿類(lèi)化合物是由天然萜類(lèi)化合物進(jìn)行結(jié)構(gòu)改造而設(shè)計(jì)合成的一類(lèi)具有抗炎活性的化合物。構(gòu)效關(guān)系研究顯示二(2-噻吩基亞甲基)環(huán)戊酮曼尼希堿類(lèi)化合物抗炎活性較強(qiáng)。(2E,5E)-2,5-二(2-噻吩基亞甲基)環(huán)戊酮是其中代表性化合物。
CCT007093 (25 or 50 μM, 8 h) significantly increases the phosphorylation levels of mTOR at Ser2448, Ser2481 and Ser2159, and the phosphorylation levels of p70S6K (Thr389) and S6 (Ser235/236) are also up-regulated in transfected HEK293T cell line.
CCT007093 shows specificity for MCF-7 cells, reducing viability by 40% after 2 days with no observable effect on the growth of HeLa cells.
CCT007093 induces P38 phosphorylation at 4 h post exposure in MCF-7 cells (sensitive to PPM1D inhibition), and does not induce P38 phosphorylation in HeLa cells (relatively resistant to PPM1D inhibition).
Western Blot Analysis
| Cell Line: | HEK293T cell line. |
| Concentration: | 25 or 50 μM. |
| Incubation Time: | 8 h. |
| Result: |
The phosphorylation levels of mTOR at Ser2448, Ser2481 and Ser2159 were all significantly increased
[1]
.
The phosphorylation levels of p70S6K (Thr389) and S6 (Ser235/236) were also up-regulated [1] . |
CCT007093 (6.4 mg/kg) enhances liver regeneration and increases the survival rate of mice following major hepatectomy.
| Animal Model: | Wild-type mice. |
| Dosage: | 3.2 and 6.4 mg/kg. |
| Administration: | Injected intraperitoneally 4 times (mice were sacrificed at 36 h post-PH). |
| Result: |
Significantly improved survival in mice following major hepatectomy (80% hepatectomy).
The level of PCNA was also significantly increased in the liver of CCT007093-treated mice at 36h, 48h and 72h post-PH. |
| 報(bào)價(jià)日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱(chēng) | CAS號(hào) | 包裝 | 價(jià)格 |
| 2026/06/05 | HY-15880 | (2E,5E)-2,5-二(2-噻吩基亞甲基)環(huán)戊酮 CCT007093 | 176957-55-4 | 5 mg | 400元 |
| 2026/06/05 | HY-15880 | (2E,5E)-2,5-二(2-噻吩基亞甲基)環(huán)戊酮 CCT007093 | 176957-55-4 | 10mg | 660元 |
| 2026/06/05 | HY-15880 | (2E,5E)-2,5-二(2-噻吩基亞甲基)環(huán)戊酮 CCT007093 | 176957-55-4 | 25 mg | 1325元 |