183849-43-6
183849-43-6 結構式
基本信息
4H-1-Benzopyran-4-one, 7-[3-[4-(6-fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl]propoxy]-3-(hydroxymethyl)-
物理化學性質
常見問題列表
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D 2 Receptor 17 nM (IC 50 ) |
5-HT 2A Receptor 6.2 nM (IC 50 ) |
Abaperidone possesses good affinity for dopamine D 2 receptors, together with a greater affinity for 5-HT 2 receptors with IC 50 of 17 and 6.2 nM, reaspectively.
The time course of the inhibition of climbing behavior for a period of several hours after oral administration of either 0.5 mg/kg of Abaperidone or risperidone is tested in mice. Also is included a comparative test of catalepsy induced by Abaperidone and risperidone along several hours following oral administration at several doses in rats. A somewhat lesser induction of catalepsy is observed for Abaperidone. A study of serum prolactin levels after oral administration of Abaperidone, haloperidol, and risperidone at 5 mg/kg for either 1 or 3 days in rats. Increases in prolactin levels after oral administration of Abaperidone are smaller than those for reference drugs.