185040-32-8
185040-32-8 結(jié)構(gòu)式
基本信息
4-甲胺基-2-甲硫基-5-醛基嘧啶
2-甲硫基-4-甲氨基-5-醛基嘧啶
4-甲氨基-2-甲硫基-嘧啶-5-醛
4-甲氨基-2-甲硫基嘧啶-5-甲醛
4-(甲基氨基)-2-(甲巰基)5-嘧啶甲醛
2-(甲硫基)-4-(甲氨基)嘧啶-5-甲醛
4-(甲基胺)-2-(甲硫基)-嘧啶-5-甲醛
4-(甲基氨基)-2-(甲硫基)嘧啶-5-甲醛
4-(MethylaMino)-2-(Methylthio)pyriMidine-5-carboxald
4-MethylaMino-2-MethanethiopyriMidine-5- carboxaldehyde
4-(Methylamino)-2-(methylthio)pyrimidine-5-carbaldehyde
4-METHYLAMINO-2-METHYLSULFANYL-PYRIMIDINE-5-CARBALDEHYDE
4-(METHYLAMINO)-2-(METHYLTHIO)-5-PYRIMIDINE CARBALDEHYDE
4-(Methylamino)-2-(methylthio)pyrimidine-5-carboxaldehyde
4-(MethylaMino)-2-(Methylthio)-5-pyriMidinecarboxaldehyde
4-MethylaMino-2-Methanesulfanyl-pyriMidine-5-carboxaldehyde
5-Pyrimidinecarboxaldehyde, 4-(methylamino)-2-(methylthio)-
物理化學(xué)性質(zhì)
制備方法
17759-30-7
185040-32-8
在裝有頂置式機(jī)械攪拌器和氬氣入口的干燥3L三頸圓底燒瓶中，將32.74g（176.7mmol）(4-甲基氨基-2-甲烷磺?；?嘧啶-5-基)-甲醇溶解于1.6L氯仿中。在攪拌條件下，分批加入152g（1.75mol）二氧化錳。將反應(yīng)混合物輕微加熱并持續(xù)攪拌7小時(shí)。反應(yīng)完成后，通過(guò)硅藻土墊進(jìn)行真空過(guò)濾以除去二氧化錳，并用兩份300mL氯仿充分洗滌濾餅。合并濾液并濃縮，得到白色固體產(chǎn)物。經(jīng)真空干燥后，獲得30.6g（產(chǎn)率94%）4-甲胺基-2-甲硫基-5-醛基嘧啶。所得產(chǎn)物的光譜數(shù)據(jù)與文獻(xiàn)報(bào)道值一致。
參考文獻(xiàn)：
[1] Patent: WO2004/63195, 2004, A1. Location in patent: Page 53-54
[2] Journal of Medicinal Chemistry, 1998, vol. 41, # 17, p. 3276 - 3292
[3] Patent: WO2006/71940, 2006, A2. Location in patent: Page/Page column 355
[4] Patent: WO2008/33999, 2008, A2. Location in patent: Page/Page column 88
[5] Patent: WO2014/11900, 2014, A2. Location in patent: Page/Page column 31; 32