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18660-81-6

中文名稱 河豚毒素鹼
英文名稱 TETRODOTOXIN CITRATE
CAS 18660-81-6
分子式 C17H25N3O15
分子量 511.39
MOL 文件 18660-81-6.mol
18660-81-6 結(jié)構(gòu)式 18660-81-6 結(jié)構(gòu)式

基本信息

中文別名
河豚毒素鹼
河豚毒素檸檬酸酯鹽
英文別名
TETRODOTOXIN
TETRODOTOXIN CITRATE
citratodetetrodotoxina
tetrodotoxin,citrate(1:1)(salt)
Tetrodotoxin(TTX), with citrate
Citrato de tetrodotoxina [spanish]
Tetrodotoxin, 2-hydroxy-1,2,3-propanetricarboxylate (1:1) (salt) (9ci)
Octahydro-12-(hydroxymethyl)-2-imino-5,9:7,10a-dimethano-10aH-[1,3]dioxocino[6,5-d]pyrimidine-4,7,10,11,12-pentolcitrat
OCTAHYDRO-12-(HYDROXYMETHYL)-2-IMINO-5,9:7,10A-DIMETHANO-10AH-[1,3]DIOXOCINO[6,5-D]PYRIMIDINE-4,7,10,11,12-PENTOL CITRATE
(5R,6R,7S,9R,11R,12R,13S,14S)-3-amino-14-(hydroxymethyl)-8,10-dioxa-2,4-diazatetracyclo[7.3.1.1~7,11~.0~1,6~]tetradec-3-ene-5,9,12,13,14-pentol 2-hydroxypropane-1,2,3-tricarboxylate (1:1) (non-preferred name)

物理化學(xué)性質(zhì)

儲存條件Desiccate at -20°C
溶解度Citrate Buffer (pH 4.8): 30 mg/ml (100 mM)
酸度系數(shù)(pKa)8.76(at 25℃)
形態(tài)固體
水溶解性溶于水至100mM
穩(wěn)定性Unstable in Acidic solution, Unstable In Acidic Solution

安全數(shù)據(jù)

危險性符號(GHS)有毒 (GHS06)
GHS06
警示詞危險
危險性描述H300-H330-H310
危險品標(biāo)志T+
危險類別碼26/27/28
安全說明22-36/37/39-45
RTECS號IO1450000
毒性A toxin contained in the ovary and liver of puffer fish, in the eggs of the California newt and in some other animals. It is used as a chemical tool for the study of ion channels. The s.c. LD50 in mice is 10 mg/kg. It is a toxicant of nerve and muscle by blocking sodium channels, this action causing nerve and muscle paralysis. Symptoms include weakening of voluntary muscles, respiratory failure from paralysis of the diaphragm and hypotension. There is no antidote. Therapy involves artificial respiration.
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