18696-26-9
中文名稱
芥子堿
英文名稱
Sinapine
CAS
18696-26-9
分子式
[C16H24NO5]+.
MOL 文件
18696-26-9.mol
更新日期
2026/06/08 11:47:39
18696-26-9 結(jié)構(gòu)式
基本信息
中文別名
芥子堿(標準品) 英文別名
SinapinSinapic acid choline ester
2-[[3-(4-Hydroxy-3,5-dimethoxyphenyl)-1-oxo-2-propenyl]oxy]-N,N,N-trimethylethanaminium
2-[[3-(4-Hydroxy-3,5-dimethoxyphenyl)-1-oxo-2-propen-1-yl]oxy]-N,N,N-trimethylethanaminium
Ethanaminium, 2-((3-(4-hydroxy-3,5-dimethoxyphenyl)-1-oxo-2-propenyl)o xy)-N,N,N-trimethyl-
Ethanaminium,2-[[3-(4-hydroxy-3,5-dimethoxyphenyl)-1-oxo-2-propen-1-yl]oxy]-N,N,N-trimethyl-
2-((3-(4-hydroxy-3,5-dimethoxyphenyl)-1-oxo-2-propenyl)o xy)-N,N,N-trimethyl-2-[[3-(4-Hydroxy-3,5-dimethoxyphenyl)-1-oxo-2-propenyl]oxy]-N,N,N-trimethylethanaminium
所屬類別
分析化學：中藥標準品物理化學性質(zhì)
熔點178℃
儲存條件4°C, away from moisture and light
溶解度DMSO : 250 mg/mL (805.52 mM; Need ultrasonic)
形態(tài)粉末
顏色Off-white to yellow
InChIInChI=1S/C16H23NO5/c1-17(2,3)8-9-22-15(18)7-6-12-10-13(20-4)16(19)14(11-12)21-5/h6-7,10-11H,8-9H2,1-5H3/p+1
InChIKeyHUJXHFRXWWGYQH-UHFFFAOYSA-O
SMILESC1(O)=C(OC)C=C(C=C1OC)/C=C/C(OCC[N+](C)(C)C)=O
LogP-3.370 (est)
芥子堿價格(試劑級)
| 報價日期 | 產(chǎn)品編號 | 產(chǎn)品名稱 | CAS號 | 包裝 | 價格 |
| 2026/06/05 | HY-N5077 | 芥子堿 Sinapine | 18696-26-9 | 1 mg | 342元 |
| 2026/06/05 | HY-N5077 | 芥子堿 Sinapine | 18696-26-9 | 5 mg | 780元 |
| 2026/06/05 | HY-N5077 | 芥子堿 Sinapine | 18696-26-9 | 10 mM * 1 mL in DMSO | 858元 |
常見問題列表
生物活性
Sinapine 是一種從十字花科物種的種子中分離出來的生物堿，具有抗氧化、抗腫瘤和放射防護的作用。Sinapine 通過下調(diào) P-glycoprotein 來抑制Caco-2細胞的增殖。靶點
| Target | Value |
|
P-glycoprotein
() |
體外研究
Sinapine (6 or 60 μM; 1 h) counteracts H
2
O
2
and antimycin A-induced mitochondrial oxidative stress in cardiomyocytes.
Sinapine (10-200 μM; 24 h) inhibits the proliferation of Caco-2 cells in a dose-dependent manner, and has relatively low toxicity.
Sinapine (10-200 μM; 24 h) promotes doxorubicin accumulation in Caco-2 cell by inducing P-glycoprotein (P-gp) decrease.
Sinapine (10-200 μM; 24 h) significantly reduces phosphorylation of FRS2α, ERK1/2.
體內(nèi)研究
Sinapine reduces non-alcoholic fatty liver disease in mice by modulating the composition of the gut microbiota.