187269-40-5

中文名稱 Bimosiamose

英文名稱 Bimosiamose

CAS 187269-40-5

分子式 C46H54O16

分子量 862.92

MOL 文件 187269-40-5.mol

187269-40-5 結(jié)構(gòu)式

基本信息物理化學(xué)性質(zhì) 安全數(shù)據(jù) Bimosiamose價(jià)格(試劑級(jí)) 常見(jiàn)問(wèn)題列表

基本信息

中文別名

比莫西糖

英文別名

TBC-1269
Bimosiamose
[1,1'-Biphenyl]-3-acetic acid, 3',3'''-(1,6-hexanediyl)bis[6'-(α-D-mannopyranosyloxy)-

物理化學(xué)性質(zhì)

熔點(diǎn)115-117°

沸點(diǎn)1051.0±65.0 °C(Predicted)

密度1.417±0.06 g/cm3(Predicted)

儲(chǔ)存條件-20°C儲(chǔ)存

溶解度DMSO:100.0(Max Conc. mg/mL);115.89(Max Conc. mM)
0.1 M NaOH:25.0(Max Conc. mg/mL);28.97(Max Conc. mM)

酸度系數(shù)(pKa)3.95±0.10(Predicted)

形態(tài)結(jié)晶固體

顏色White to off-white

安全數(shù)據(jù)

危險(xiǎn)性符號(hào)(GHS) 有害 (GHS07)

GHS07

警示詞警告

危險(xiǎn)性描述H302-H315-H319-H335

防范說(shuō)明P261-P280-P301+P312-P302+P352-P305+P351+P338

Bimosiamose價(jià)格(試劑級(jí))

報(bào)價(jià)日期	產(chǎn)品編號(hào)	產(chǎn)品名稱	CAS號(hào)	包裝	價(jià)格
2026/06/05	HY-106139R	Bimosiamose Bimosiamose (Standard)	187269-40-5	1 mg	1650元
2026/06/05	HY-106139	Bimosiamose Bimosiamose	187269-40-5	1mg	600元
2026/06/05	HY-106139R	Bimosiamose Bimosiamose (Standard)	187269-40-5	5 mg	4950元

常見(jiàn)問(wèn)題列表

生物活性

Bimosiamose (TBC-1269) 是一種非寡糖泛-selectin 拮抗劑，對(duì) E-selectin，P-selectin 和 L-selectin 的 IC50 分別為 88 μM，20 μM 和 86μM。Bimosiamose 具有抗炎作用。

靶點(diǎn)

IC50: 88 μM (E-selectin), 20 μM (P-selectin), 86 μM (L-selectin)

體外研究

Bimosiamose (TBC-1269) operates by inhibiting neutrophil recruitment to the site of inflammation through blocking the initial rolling phase of recruitment. Bimosiamose (TBC-1269) inhibits cell recruitment and does not possess any cytotoxic effect on neutrophils.

體內(nèi)研究

Bimosiamose (TBC-1269; 25 mg/kg; intravenous injection; Sprague-Dawley rats) treatment shows a significant increase in survival. Best overall survival, 70%, is observed when TBC-1269 is administered 15 minutes before reperfusion, and also shows a marked decrease in liver enzyme levels at 6 hours after reperfusion. Neutrophil migration is also significantly ameliorated (81%). The histologic damage scores is also improved.