187523-35-9

中文名稱 (3S)-3-(5-chloro-2-methoxy-phenyl)-3-fluoro-6-(trifluoromethyl)-1H-ind ol-2-one

英文名稱 (3S)-3-(5-chloro-2-methoxy-phenyl)-3-fluoro-6-(trifluoromethyl)-1H-ind ol-2-one

CAS 187523-35-9

分子式 C16H10ClF4NO2

分子量 359.7

MOL 文件 187523-35-9.mol

更新日期 2026/07/15 17:50:24

187523-35-9 結(jié)構(gòu)式

基本信息物理化學(xué)性質(zhì) 安全數(shù)據(jù) 圖譜信息 (3S)-3-(5-chloro-2-methoxy-phenyl)-3-fluoro-6-(trifluoromethyl)-1H-ind ol-2-one價格(試劑級) 常見問題列表

基本信息

中文別名

化合物FLINDOKALNER

英文別名

MaxiPost
FLINDOKALNER
BMS-204352 (BMS 204352
(3S)-3-(5-chloro-2-methoxy-phenyl)-3-fluoro-6-(trifluoromethyl)-1H-ind ol-2-one
(3S)-3-(5-Chloro-2-methoxyphenyl)-3-fluoro-1,3-dihydro-6-(trifluoromethyl)-2H-Indol-2-one
2H-Indol-2-one, 3-(5-chloro-2-methoxyphenyl)-3-fluoro-1,3-dihydro-6-(trifluoromethyl)-, (3S)-

物理化學(xué)性質(zhì)

沸點436.9±45.0 °C(Predicted)

密度1.50±0.1 g/cm3(Predicted)

儲存條件-20°C儲存

溶解度Soluble to 100 mM in DMSO and to 100 mM in ethanol

酸度系數(shù)(pKa)10.43±0.40(Predicted)

形態(tài)粉末

顏色White to off-white

InChIInChI=1S/C16H10ClF4NO2/c1-24-13-5-3-9(17)7-11(13)15(18)10-4-2-8(16(19,20)21)6-12(10)22-14(15)23/h2-7H,1H3,(H,22,23)/t15-/m0/s1

InChIKeyULYONBAOIMCNEH-HNNXBMFYSA-N

SMILESN1C2=C(C=CC(C(F)(F)F)=C2)[C@@](C2=CC(Cl)=CC=C2OC)(F)C1=O

安全數(shù)據(jù)

危險性符號(GHS) 有害 (GHS07)

GHS07

警示詞警告

危險性描述H315-H319-H335

防范說明P261-P264-P271-P280-P302+P352-P305+P351+P338

圖譜信息

(3S)-3-(5-chloro-2-methoxy-phenyl)-3-fluoro-6-(trifluoromethyl)-1H-ind ol-2-one(187523-35-9)核磁圖(¹HNMR)

(3S)-3-(5-chloro-2-methoxy-phenyl)-3-fluoro-6-(trifluoromethyl)-1H-ind ol-2-one價格(試劑級)

報價日期	產(chǎn)品編號	產(chǎn)品名稱	CAS號	包裝	價格
2026/06/05	HY-108584	Flindokalner	187523-35-9	1 mg	421元
2026/06/05	HY-108584	(3S)-3-(5-chloro-2-methoxy-phenyl)-3-fluoro-6-(trifluoromethyl)-1H-ind ol-2-one Flindokalner	187523-35-9	5mg	960元
2026/06/05	HY-108584R	(3S)-3-(5-chloro-2-methoxy-phenyl)-3-fluoro-6-(trifluoromethyl)-1H-ind ol-2-one Flindokalner (Standard)	187523-35-9	5 mg	2716元

常見問題列表

生物活性

Flindokalner (BMS-204352) 是鉀離子通道 (potassium channel) 調(diào)節(jié)劑。Flindokalner 是在 HEK293 細胞中表達的所有神經(jīng)元 Kv7 通道亞型的正調(diào)節(jié)劑。Flindokalner 是一種大電導(dǎo)鈣激活 K 通道 (BKca) 正向調(diào)節(jié)劑。Flindokalner 在 Kv7.1 通道 (Ki=3.7 μM) 處顯示負調(diào)節(jié)活性，并充當(dāng) GABAA 受體的負調(diào)節(jié)劑。Flindokalner 在體內(nèi)顯示出抗焦慮功效。

靶點

Ki: 3.7 μM (Kv7.1), 230 μM (Kv7.4), 605 μM (Kv7.5)

體外研究

Flindokalner (BMS-204352) (10 μM) inhibits Kv7.4and Kv7.5 with K _i s of 230 and 605 μM, respectively.
Flindokalner (1-10 μM) causes inhibition of the Ca ²⁺ current in a dose-dependent manner, with a Kd of 6 μM and a Hill coefficient of 1.33. Flindokalnerinhibits cardiac L-type Ca ²⁺ channels in a direct manner, without affecting BKCa channels or intracellular signal transduction, in freshly isolated rat ventricular myocytes.

體內(nèi)研究

Flindokalner (BMS-204352) (3-30 mg/kg; i.p.) induces a dose-dependent anxiolytic effect.
In shock-based conditioned model of anxiety in male Wistar rats, Flindokalner (3-60 mg/kg; i.p.) engenderes an anxiolytic profile.

Animal Model:	Female NMRI or male C57 mice (20-25 g) (Anxiolytic Models)
Dosage:	i.p.
Administration:	3, 10, 30 mg/kg
Result:	Significantly and dose dependently increased time spent in the open areas, reduced latency to enter an open area, and increased the number of entries in to the open areas in Zero Maze.