188116-07-6
188116-07-6 結(jié)構(gòu)式
基本信息
1-(4-氯苯基)-1,5-二氫-4-(4-嗎啉基)-2H-咪唑-2-酮
ELB-138
Imepitoin
AWD 131-13
AWD 131-138, >=98%
IMEPITOIN
AWD131-138
AWD 131-138(Imepitoin)
3-(4-chlorophenyl)-5-morpholin-4-yl-4H-imidazol-2-one
1-(4-chlorophenyl)-4-morpholin-4-yl-5H-imidazol-2-one
1-(4-CHLOROPHENYL)-4-MORPHOLINO-1H-IMIDAZOL-2(5H)-ONE
物理化學(xué)性質(zhì)
DMSO:17.5(Max Conc. mg/mL);62.56(Max Conc. mM)
DMSO:PBS (pH 7.2) (1:1):0.5(Max Conc. mg/mL);1.79(Max Conc. mM)
Ethanol:1.13(Max Conc. mg/mL);4.02(Max Conc. mM)
| 報(bào)價(jià)日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱 | CAS號(hào) | 包裝 | 價(jià)格 |
| 2026/03/03 | S5319 | 伊匹妥英 AWD 131-138 | 188116-07-6 | 5mg | 1204.02元 |
| 2025/12/22 | HY-14953 | 伊匹妥英 Imepitoin | 188116-07-6 | 1 mg | 245元 |
| 2025/12/22 | HY-14953 | 伊匹妥英 Imepitoin | 188116-07-6 | 5mg | 545元 |
常見問題列表
GABA receptor
AWD 131-138 dose-dependently stimulated GABA currents(Recombinant gamma-aminobutyric acid A (GABA(A)) receptors of the subunit compositions alpha1beta2gamma2, alpha1beta3gamma2, alpha2beta2gamma2, alpha3beta2gamma2 and alpha5beta2gamma2). At 10 microM AWD 131-138, this allosteric stimulation amounted in average to about 12-21% of the maximal stimulation achieved using diazepam. The threshold of stimulation was about 0.3-1.0 microM [1].
AWD 131-138 did not produce midazolam-like responding or alter response rates at cumulative doses up to 18.0 mg/kg i.m. (plasma levels over 2100 ng/ml). When AWD 131-138 (10-100 microg/kg/injection) was studied by substitution, responding declined to vehicle substitution levels within three sessions. At the dose of 100 microg/kg i.v. AWD 131-138, sufficient drug was self-administered during the first session (about 3.5 mg/kg) to produce plasma levels above 1000 ng/ml, yet responding over the next two sessions dropped to vehicle levels [2]. Prolonged oral administration with twice-daily dosing of ELB 138 with either 5 or 40 mg/kg over a 5-week period was not associated with loss of anticonvulsant efficacy in the PTZ dog model [3].