18877-64-0
中文名稱
L-氯化棕櫚酰肉堿
英文名稱
Palmitoyl-L-Carnitine Chloride
CAS
18877-64-0
分子式
C23H46ClNO4
分子量
436.07
MOL 文件
18877-64-0.mol
更新日期
2026/05/25 12:34:58
18877-64-0 結(jié)構(gòu)式
基本信息
中文別名
氯化棕櫚酰L-棕櫚?；鈮A
L-氯化棕櫚酰肉堿
左旋棕櫚酰肉堿鹽酸鹽
棕櫚酰-L-肉堿鹽酸鹽
棕櫚酰-L-肉堿氯化物
L-肉堿:鹽酸鹽,O-棕櫚酰未標(biāo)記
棕櫚酰-L-肉堿鹽酸鹽
英文別名
Einecs 242-642-6L-CARNITINE:HCL, O-PALMITOYL
L-Palmitoylcarnitine chloride
PALMITOYL-L-CARNITINE CHLORIDE
O-PALMITOYL-L-CARNITINE CHLORIDE
HEXADECANOYL-L-CARNITINE CHLORIDE
Palmitoyl-L-carnitine hydrochloride
Palmitoyl-L-carnitine chloride≥ 99% (TLC)
(R)-3-(Palmitoyloxy)-4-(trimethylammonio)butanoate Hydrochloride
(R)-3-(Hexadecanoyloxy)-4-(trimethylammonio)butyrate Hydrochloride
所屬類別
生物化工：堿基·核酸·衍生物物理化學(xué)性質(zhì)
熔點(diǎn)168-172 °C(lit.)
儲(chǔ)存條件−20°C
溶解度H2O: 25 mg/mL with heat or sonication
形態(tài)powder
顏色white
外觀white solid
水溶解性H2O: 25mg/mL (with he at or sonication)
BRN4071005
InChIInChI=1/C23H45NO4.ClH/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(27)28-21(19-22(25)26)20-24(2,3)4;/h21H,5-20H2,1-4H3;1H/t21-;/s3
InChIKeyGAMKNLFIHBMGQT-GKNLIIIVNA-N
SMILES[C@@H](CC(=O)O)(C[N+](C)(C)C)OC(=O)CCCCCCCCCCCCCCC.[Cl-] |&1:0,r|
CAS 數(shù)據(jù)庫(kù)18877-64-0
安全數(shù)據(jù)
警示詞警告
危險(xiǎn)性描述H315-H319-H335
危險(xiǎn)品標(biāo)志Xi
危險(xiǎn)類別碼36/37/38
安全說(shuō)明26-36
WGK Germany3
F3-10
海關(guān)編碼2923900090
L-氯化棕櫚酰肉堿價(jià)格(試劑級(jí))
| 報(bào)價(jià)日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱 | CAS號(hào) | 包裝 | 價(jià)格 |
| 2025/12/22 | HY-113147A | L-氯化棕櫚酰肉堿 L-Palmitoylcarnitine chloride | 18877-64-0 | 1 mg | 454元 |
| 2025/12/22 | HY-113147A | L-氯化棕櫚酰肉堿 L-Palmitoylcarnitine chloride | 18877-64-0 | 5mg | 1000元 |
| 2025/12/22 | HY-113147A | L-氯化棕櫚酰肉堿 L-Palmitoylcarnitine chloride | 18877-64-0 | 10 mM * 1 mLin DMSO | 1100元 |
常見(jiàn)問(wèn)題列表
生物活性
L-Palmitoylcarnitine chloride是一種長(zhǎng)鏈酰基肉堿和脂肪酸代謝產(chǎn)物，在缺血期間積聚于肌膜并擾亂膜脂環(huán)境。L-Palmitoylcarnitine chloride 通過(guò)與 Kir6.2 的相互作用抑制 KATP 通道活性，而不影響單通道電導(dǎo)。靶點(diǎn)
|
Kir6.2
|
Human Endogenous Metabolite
|
體外研究
L-Palmitoylcarnitine (1 μM) inhibits KATP channel activity, without affecting the single channel conductance, through interaction with Kir6.2. L-Palmitoylcarnitine simultaneously enhances the ATP sensitivity of the channel (IC
50
fell from 62 to 30 μM).
Modulation of the membrane lipid environment caused by L-Palmitoylcarnitine alters the K
ATP
channel function mainly through the interaction with endogenous PI cascade, especially PIP2.