192718-06-2

中文名稱 192718-06-2

英文名稱 2-(4-Fluorophenyl)naphtho[2,3-d]oxazole-4,9-dione

CAS 192718-06-2

分子式 C17H8FNO3

分子量 293.25

MOL 文件 192718-06-2.mol

192718-06-2 結(jié)構(gòu)式

基本信息物理化學(xué)性質(zhì) 安全數(shù)據(jù) 圖譜信息 192718-06-2價(jià)格(試劑級(jí)) 常見問題列表

基本信息

中文別名

2-(4-氟苯基)萘并[2,3-D]惡唑-4,9-二酮

英文別名

C527
C527 >=98% (HPLC)
2-(4-Fluorophenyl)-naphth[2,3-d]oxazole-4,9-dione
2-(4-Fluorophenyl)naphtho[2,3-d]oxazole-4,9-dione
Naphth[2,3-d]oxazole-4,9-dione, 2-(4-fluorophenyl)-

物理化學(xué)性質(zhì)

沸點(diǎn)488.6±47.0 °C(Predicted)

密度1.433±0.06 g/cm3(Predicted)

儲(chǔ)存條件Sealed in dry,Room Temperature

溶解度在DMSO中的溶解度為0.3mg/mL，澄清（加熱）

酸度系數(shù)(pKa)-4.21±0.20(Predicted)

形態(tài)粉末

顏色淡黃色至深黃色

安全數(shù)據(jù)

危險(xiǎn)性符號(hào)(GHS) 有害 (GHS07)

GHS07

警示詞警告

危險(xiǎn)性描述H302

防范說明P280-P305+P351+P338

危險(xiǎn)品標(biāo)志Xn

危險(xiǎn)類別碼22

安全說明46

WGK Germany3

圖譜信息

192718-06-2(192718-06-2)核磁圖(¹HNMR)

192718-06-2價(jià)格(試劑級(jí))

報(bào)價(jià)日期	產(chǎn)品編號(hào)	產(chǎn)品名稱	CAS號(hào)	包裝	價(jià)格
2026/06/05	HY-12988	C527	192718-06-2	1 mg	120元
2026/06/05	HY-12988	192718-06-2 C527	192718-06-2	5mg	300元
2026/06/05	HY-12988	192718-06-2 C527	192718-06-2	10mg	500元

常見問題列表

生物活性

C527是泛 DUB 酶的抑制劑，對(duì) USP1/UAF1 復(fù)合物活性較高， IC50 值為0.88 μM。

靶點(diǎn)

0.88 μM (USP1)

體外研究

Pretreatment of USP1/UAF1 with C527 resulted in inhibition of its enzyme activity with an IC ₅₀ of 0.88±0.03 μM. C527 inhibits the DUB activity of the USP12/USP46 complex and other DUB enzymes in vitro . However, the IC ₅₀ of C527 for these DUB enzymes was higher in comparison with USP1/UAF1 complex. C527 has considerably less inhibitory effect on UCH-L1 and UCH-L3, a different subclass of DUB enzymes. C527 treatments causes an increase in the levels of Ub-FANCD2 and Ub-FANCI. Pretreatment of cells with the C527 causes an enhancement in the cytoxicity of mitomycin C and camptothecin. C527 treatments lead to an increase in ubiquitinated forms of FANCD2 and FANCI, cause a decrease in homologous recombination activity, and sensitize cells to DNA damaging agents.