1995893-58-7
中文名稱
FEN1 Inhibitor C2
英文名稱
FEN1 Inhibitor C2
CAS
1995893-58-7
分子式
C12H12N2O3
分子量
232.24
MOL 文件
1995893-58-7.mol
更新日期
2026/05/22 12:33:43
1995893-58-7 結(jié)構(gòu)式
基本信息
中文別名
1-(環(huán)丙基甲基)-3-羥基喹唑啉-2,4(1H,3H)-二酮 英文別名
FEN1-IN-4FEN1 Inhibitor C2
2,4(1H,3H)-Quinazolinedione, 1-(cyclopropylmethyl)-3-hydroxy-
物理化學(xué)性質(zhì)
儲存條件Inert atmosphere,Store in freezer, under -20°C
溶解度DMSO: 125 mg/mL (538.24 mM)
形態(tài)Solid
顏色Light yellow to yellow
FEN1 Inhibitor C2價格(試劑級)
| 報價日期 | 產(chǎn)品編號 | 產(chǎn)品名稱 | CAS號 | 包裝 | 價格 |
| 2026/03/03 | S3397 | FEN1 Inhibitor C2 FEN1-IN-4 | 1995893-58-7 | 5mg | 1547.91元 |
| 2026/03/03 | S3397 | FEN1-IN-4 | 1995893-58-7 | 10mM (1mL in DMSO) | 1793.61元 |
| 2026/03/03 | S3397 | FEN1 Inhibitor C2 FEN1-IN-4 | 1995893-58-7 | 25mg | 4643.73元 |
常見問題列表
生物活性
FEN1-IN-4 (Compound 2) 是一種人類皮瓣內(nèi)切核酸酶-1 (hFEN1) 抑制劑。靶點
hFEN1
體外研究
FEN1 inhibition selectively impairs proliferation of colon cancer cells deficient in Cdc4 and Mre11a , both frequently mutated in colorectal cancers. FEN1 has also emerged as a potential chemosensitizing target due to its role in LP-BER since it is critical for repair of Methyl methanesulfonate-induced alkylation damage, and its knockdown or inhibition increases sensitivity to Temozolomide in glioblastoma and colorectal cancer cell lines.