2011-48-5
2011-48-5 結(jié)構(gòu)式
基本信息
4-甲氧基芐肼雙鹽酸鹽
(4-甲氧苯基)肼二鹽酸鹽
(4-甲氧基芐基)肼鹽酸鹽
(4-甲氧苯基)肼二鹽酸鹽 100G
[(4-甲氧基苯基)甲基]-肼鹽酸鹽
4-甲氧基芐肼鹽酸鹽/(4-甲氧苯基)肼鹽酸鹽
(4-Methoxybenzyl)hydrazinehydrochloride
(4-METHOXYBENZYL)HYDRAZINE DIHYDROCHLORIDE
p-Methoxybenzylhydrazine monohydrochloride
Hydrazine, p-methoxybenzyl-, hydrochloride
[(4-methoxyphenyl)methyl]hydrazine hydrochloride
Hydrazine, [(4-Methoxyphenyl)Methyl]-, hydrochloride (1:1)
物理化學(xué)性質(zhì)
安全數(shù)據(jù)
制備方法
824-94-2
2011-48-5
步驟1: (4-甲氧基芐基)肼鹽酸鹽的合成 向500 mL三頸圓底燒瓶中加入水合肼(40 g, 0.80 mol)和無水乙醇(280 mL)。在室溫下，緩慢滴加4-甲氧基芐基氯(12.5 g, 0.080 mol)的無水乙醇(30 mL)溶液至上述混合液中。將反應(yīng)混合物加熱至90℃并攪拌2小時(shí)。反應(yīng)完成后，將混合物在減壓下濃縮以去除溶劑，隨后將殘余物重新溶解于無水乙醇(150 mL)中。將溶液冷卻至0℃，緩慢加入5M鹽酸(120 mL)進(jìn)行酸化。通過過濾收集析出的白色固體沉淀，干燥后得到目標(biāo)產(chǎn)物(4-甲氧基芐基)肼鹽酸鹽8.72 g，收率72%。質(zhì)譜分析顯示m/z: 153(M+H)+。
參考文獻(xiàn)：
[1] Patent: US2010/120741, 2010, A1. Location in patent: Page/Page column 87
[2] Patent: WO2011/112731, 2011, A2. Location in patent: Page/Page column 189-190
[3] Patent: WO2014/139150, 2014, A1. Location in patent: Page/Page column 84; 85
[4] Patent: WO2014/150114, 2014, A1. Location in patent: Page/Page column 84; 85
[5] Patent: US2017/145026, 2017, A1. Location in patent: Paragraph 1027; 1028