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209467-52-7

中文名稱 頭孢吡普
英文名稱 Ceftobiprole
CAS 209467-52-7
分子式 C20H22N8O6S2
分子量 534.57
MOL 文件 209467-52-7.mol
更新日期 2026/05/26 09:49:51
209467-52-7 結(jié)構(gòu)式 209467-52-7 結(jié)構(gòu)式

基本信息

中文別名
頭孢吡普
英文別名
CS-734
BAL 9141
Ceftobiprole
5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylicacid,7-[[(2Z)-2-(5-aMino-1,2,4-thiadiazol-3-yl)-2-(hydroxyiMino)acetyl]aMino]-8-oxo-3-[(E)-[(3'R)-2-oxo[1,3'-bipyrrolidin]-3-ylidene]Methyl]-,(6R,7R)-

物理化學性質(zhì)

密度2.00±0.1 g/cm3(Predicted)
儲存條件Store at -20°C,unstable in solution, ready to use.
溶解度DMSO : 5 mg/mL (9.35 mM)
酸度系數(shù)(pKa)2.46±0.50(Predicted)
形態(tài)Solid
顏色Light yellow to yellow
InChIKeyVOAZJEPQLGBXGO-SDAWRPRTSA-N
SMILESN12[C@@]([H])([C@H](NC(/C(/C3N=C(N)SN=3)=N\O)=O)C1=O)SCC(/C=C1\CCN([C@@H]3CCNC3)C\1=O)=C2C(O)=O

安全數(shù)據(jù)

警示詞危險
危險性描述H334-H317-H302
WGK GermanyWGK 3
存儲類別11 - Combustible Solids
頭孢吡普價格(試劑級)
報價日期產(chǎn)品編號產(chǎn)品名稱CAS號包裝價格
2025/12/22HY-112579頭孢吡普
Ceftobiprole
209467-52-71 mg997元
2025/12/22HY-112579頭孢吡普
Ceftobiprole
209467-52-75mg2570元
2025/12/22HY-112579頭孢吡普
Ceftobiprole
209467-52-710mg3730元

常見問題列表

生物活性
Ceftobiprole (Ro 63-9141) 是一種廣譜頭孢菌素,可有效作用于甲氧西林耐受的金黃色葡萄球菌 (MRSA),MIC90 值為 2 μg/mL。
靶點

MIC90: 2 μg/mL (MRSA)

體外研究

Ceftobiprole has demonstrates activity against important gram-positive bacteria, including S. pneumonia (PRSP), Methicillin-resistant S. aureus (MRSA), and E. faecalis with MIC 90 values of 0.25, 2, and 2 mcg/mL, respectively. Ceftobiprole has also demonstrated potent in vitro activity against several clinical isolates of community-associated Methicillin-resistant S. aureus (CA-MRSA), S. aureus (VISA), and S. aureus (VRSA), with a minimum inhibitory concentration (MIC) of 2 mcg/mL. Ceftobiprole is highly active against S. aureus, withMICs ranging from 0.12 to 4 mg/L (only one resistant strain,MIC of 4 mg/L). Furthermore, Ceftobiprole is twice more active on Methicillin-susceptible S. aureus (MSSA) strains with MIC 50 and MIC 90 of 0.5 mg/L than on MRSA strains with MIC 50 and MIC 90 of 1 mg/L. Moreover, Panton-Valentine leukocidin (PVL)+MRSA are slightly more susceptible to Ceftobiprole (MIC 50 of 0.5 mg/L and MIC 90 of 1 mg/L) than PVL-MRSA (MIC 50 and MIC 90 of 1 mg/L).

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