21104-28-9
中文名稱(chēng)
馬漢九里香堿
英文名稱(chēng)
Mahanimbine
CAS
21104-28-9
分子式
C23H25NO
分子量
331.45
MOL 文件
21104-28-9.mol
更新日期
2025/06/26 17:18:34
21104-28-9 結(jié)構(gòu)式
基本信息
中文別名
月桔賓馬漢九里香堿
(+)-3,11-二氫-3,5-二甲基-3-(4-甲基-3-戊烯-1-基)吡喃并[3,2-A]咔唑
英文別名
MahanimbinMahanimbine
(+)-3,11-Dihydro-3,5-dimethyl-3-(4-methyl-3-penten-1-yl)pyrano[3,2-a]carbazole
Pyrano[3,2-a]carbazole, 3,11-dihydro-3,5-dimethyl-3-(4-methyl-3-penten-1-yl)-, (3S)-
所屬類(lèi)別
天然產(chǎn)物：生物堿物理化學(xué)性質(zhì)
熔點(diǎn)94-95 °C
沸點(diǎn)502.6±39.0 °C(Predicted)
密度1.109
溶解度DMSO: 10 mM
酸度系數(shù)(pKa)17.31±0.40(Predicted)
形態(tài)neat
穩(wěn)定性Light Sensitive
馬漢九里香堿價(jià)格(試劑級(jí))
| 報(bào)價(jià)日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱(chēng) | CAS號(hào) | 包裝 | 價(jià)格 |
| 2026/06/05 | HY-124557 | 馬漢九里香堿 Mahanimbine | 21104-28-9 | 1mg | 1920元 |
| 2026/06/05 | HY-124557 | 馬漢九里香堿 Mahanimbine | 21104-28-9 | 5mg | 4800元 |
常見(jiàn)問(wèn)題列表
生物活性
Mahanimbine 是咖喱葉中的一種具有口服活性的生物堿。Mahanimbine 抑制高脂飲食 (HFD) 誘導(dǎo)的小鼠代謝并發(fā)癥的進(jìn)展。體內(nèi)研究
Mahanimbine (2-4 mg/kg; p.o.; daily for 12 weeks) prevents HFD-induced weight gain in mice (male and female).
Mahanimbine prevented HFD-induced hyperlipidemia and fat accumulation in adipose tissue and liver along with the restricted progression of systemic inflammation and oxidative stress.
Mahanimbine treatment improves glucose clearance and upregulates the expression of insulin responsive genes in liver and adipose tissue.
| Animal Model: | Swiss albino mice (7-8 weeks old, both sex) |
| Dosage: | HFD+LD (2 mg/kg of body weight of mahanimbine), HFD+HD (4 mg/kg of body weight of mahanimbine); |
| Administration: | Oral suspension; daily for 12 weeks |
| Result: | Male HFD+LD and HFD+HD groups showed 51.70±6 3.59% and 47.37±3.73% weight gain, respectively, as compared with 71.02±6 6.04% in HFD fed mice whereas female HFD+LD and HFD+HD groups showed 24.31±1.68% and 25.10±2.61% weight gain as compared with HFD group with 36.69±3.60% of weight gain. |