221289-88-9
221289-88-9 結(jié)構(gòu)式
基本信息
2,3-二氫-2-氧代-1H-苯并咪唑-5-甲腈
2,3-二氫-2- 氧代-1H-苯并咪唑-5-腈
2-氧代-2,3-二氫-1H-苯并[D]咪唑-5-腈
2,3-二氫-2- 氧代-1H-苯并咪唑-5-腈 5G
2-氧代-2,3-二氫-1H-苯并[D]咪唑-5-甲腈
2-oxo-2,3-dihydrobenzimidazole-5-carbonitirle ?
2,3-DIHYDRO-2-OXO-1H-BENZIMIDAZOLE-5-CARBONITRILE
2-Oxo-2,3-dihydro-1H-benzimidazole-5-carbonitrile
1H-BenziMidazole-5-carbonitrile, 2,3-dihydro-2-oxo-
2-oxo-2,3-dihydro-1H-1,3-benzodiazole-5-carbonitrile
1H-Benzimidazole-5-carbonitrile,2,3-dihydro-2-oxo-(9CI)
2-oxo-2,3-dihydro-1H-benzimidazole-5-carbonitrile(SALTDATA: FREE)
物理化學(xué)性質(zhì)
制備方法
17626-40-3
530-62-1
221289-88-9
在室溫及氬氣保護(hù)下，將3,4-二氨基苯甲腈（200 mg，1.5 mmol）溶于THF（10 mL）中，隨后加入N,N'-羰基二咪唑（243 mg，1.5 mmol）。反應(yīng)混合物攪拌16小時。反應(yīng)完成后，通過減壓蒸餾去除溶劑。粗產(chǎn)物通過硅膠柱色譜法純化，洗脫劑為40%丙酮/己烷，得到2-氧代-2,3-二氫-1H-苯并[d]咪唑-5-甲腈（60 mg，0.37 mmol，產(chǎn)率24%），為灰白色固體。1H NMR (400 MHz, DMSO-d6): δ 11.16 (br s, 1H), 11.04 (br s, 1H), 7.39 (dd, J = 8.1, 1.6 Hz, 1H), 7.30 (s, 1H), 7.06 (d, J = 8.2 Hz, 1H)。
參考文獻(xiàn)：
[1] Journal of Medicinal Chemistry, 2006, vol. 49, # 12, p. 3719 - 3742
[2] Patent: WO2017/117393, 2017, A1. Location in patent: Page/Page column 263
[3] Patent: EP2003132, 2008, A1. Location in patent: Page/Page column 23
[4] Bioorganic and Medicinal Chemistry Letters, 2012, vol. 22, # 17, p. 5392 - 5395
[5] Patent: WO2018/81167, 2018, A1. Location in patent: Page/Page column 244