226954-04-7

中文名稱 N/A

英文名稱 AC-5216

CAS 226954-04-7

分子式 C23H23N5O2

分子量 401.46

MOL 文件 226954-04-7.mol

更新日期 2026/06/05 17:25:50

226954-04-7 結(jié)構(gòu)式

基本信息物理化學(xué)性質(zhì) 安全數(shù)據(jù) AC-5216價(jià)格(試劑級(jí)) 常見(jiàn)問(wèn)題列表

基本信息

中文別名

EMAPUNIL游離
EMAPUNIL游離態(tài)
N-乙基-7,8-二氫-7-甲基-8-氧代-2-苯基-N-(苯基甲基)-9H-嘌呤-9-乙酰胺
N-芐基-N-乙基-2-(7-甲基-8-氧代-2-苯基-7,8-二氫-9H-嘌呤-9-基)乙酰胺

英文別名

CS-2606
AC-5216
XBD-173
EMapunil
Emapunil(AC-5216)
AC 5216 (Emapunil)
XBD173 >=98% (HPLC)
AC-5216
XBD-173
EMAPUNIL
AC5216
AC 5216
N-Benzyl-N-ethyl-2-(7-Methyl-8-oxo-2-phenyl-7,8-dihydro-9H-purin-9-yl)acetaMide
N-Ethyl-7,8-dihydro-7-methyl-8-oxo-2-phenyl-N-(phenylmethyl)-9H-purine-9-acetamide

所屬類別

生物化工：激動(dòng)劑抑制劑

物理化學(xué)性質(zhì)

儲(chǔ)存條件2-8°C

溶解度DMF: 30 mg/mL; DMF:PBS (pH 7.2) (1:20): 0.05 mg/mL; DMSO: 5 mg/mL

形態(tài)粉末

顏色白色至米色

InChI1S/C23H23N5O2/c1-3-27(15-17-10-6-4-7-11-17)20(29)16-28-22-19(26(2)23(28)30)14-24-21(25-22)18-12-8-5-9-13-18/h4-14H,3,15-16H2,1-2H3

InChIKeyNBMBIEOUVBHEBM-UHFFFAOYSA-N

SMILESCN(C1=CN=C(C2=CC=CC=C2)N=C1N3CC(N(CC)CC4=CC=CC=C4)=O)C3=O

安全數(shù)據(jù)

危險(xiǎn)性符號(hào)(GHS) 有害 (GHS07)

GHS07

警示詞警告

危險(xiǎn)性描述H302

防范說(shuō)明P264-P270-P301+P312-P501

WGK GermanyWGK 3

存儲(chǔ)類別11 - Combustible Solids

危險(xiǎn)性類別Acute Tox. 4 Oral

AC-5216價(jià)格(試劑級(jí))

報(bào)價(jià)日期	產(chǎn)品編號(hào)	產(chǎn)品名稱	CAS號(hào)	包裝	價(jià)格
2026/06/05	HY-15527R	AC-5216 Emapunil (Standard)	226954-04-7	5 mg	1900元
2026/06/05	HY-15527	Emapunil	226954-04-7	1 mg	400元
2026/06/05	HY-15527R	AC-5216 Emapunil (Standard)	226954-04-7	10 mg	3040元

常見(jiàn)問(wèn)題列表

生物活性

Emapunil (AC-5216, 18 kiloDalton Translocator Protein, XBD173)是一種新型的 mitochondrial benzodiazepine receptor/translocator protein (MBR/TSPO) 配體。Emapunil(AC-5216) 對(duì)大鼠全腦制備的 MBRs 具有高親和力，Ki值為0.297 nM，在大鼠神經(jīng)膠質(zhì)瘤細(xì)胞和人神經(jīng)膠質(zhì)瘤細(xì)胞上的IC50值分別為 3.04 nM和 2.73 nM。

靶點(diǎn)

Target	Value
mMBR(Brain) (Cell-free assay)	0.297 nM(Ki)
MBR (human glioma cells-based assay)	2.73 nM
MBR (rat glioma cells-based assay)	3.04 nM

體內(nèi)研究

Emapunil (AC-5216, 0.1-3, 0.003-0.01 and 0.01-0.3 mg/kg, p.o.) produces anti-anxiety effects in the Vogel-type conflict test in rats, and in the light/dark box and social interaction tests in mice.
Emapunil (AC-5216, 3-30 mg/kg, p.o.) reduces the immobility time, and this effect was blocked by PK11195.
Emapunil (AC-5216, 1-100 mg/kg, p.o.) produces no distinct change in the rat electroencephalogram.
Emapunil (AC-5216, 0.3 and 1 mg/kg, i.g.) causes significant suppression of the enhanced anxiety and contextual fear induced in post-TDS rats.
Emapunil (AC-5216, 0.3 and 1 mg/kg, i.g.) alleviates the enhanced anxiety and fear response in a time-dependent sensitization (TDS) procedure, a rat PTSD animal model.
Emapunil (AC-5216, 0.3 and 1 mg/kg, i.g.) reverses the increased plasma glucose (PG) and decreased insulin (INS) in HFD-STZ rats.