2295-58-1
2295-58-1 結(jié)構(gòu)式
基本信息
三羥苯丙酮
1-(2,4,6-三羥基苯基)丙-1-酮
2,4,6-TRIHYDROXYPROPIOPHENONE
FLOPROPIONE
PHLOPROPIOPHENONE
PHLOROPROPIOPHENONE
1-(2,4,6-trihydroxyphenyl)-1-propanon
1-(2,4,6-Trihydroxyphenyl)-1-propanone
13907 R. P.
13907r.p.
1-Propanone, 1-(2,4,6-trihydroxyphenyl)-
2’,4’,6’-trihydroxy-propiophenon
Argobyl
Chlonarin
Cospanon
Ecapron
Flopion
Flopropion
Gallepronin
Gasstenon
Labroda
物理化學(xué)性質(zhì)
安全數(shù)據(jù)
制備方法
108-73-6
79-03-8
2295-58-1
通用程序：將無水AlCl3（4當(dāng)量）緩慢加入至攪拌的間苯三酚（1當(dāng)量）于CS2的懸浮液中。隨后，在30分鐘內(nèi)逐滴加入硝基苯。將反應(yīng)混合物于55℃下回流30分鐘。接著，在30分鐘內(nèi)緩慢加入溶解于硝基苯中的丙酰氯（1當(dāng)量），并繼續(xù)加熱反應(yīng)混合物30分鐘。反應(yīng)完成后，在攪拌下使混合物冷卻至室溫，隨后緩慢倒入冰水浴中。加入3M HCl以淬滅反應(yīng)。通過減壓蒸餾除去有機(jī)溶劑，所得油狀殘余物用Et2O萃取。萃取后，蒸發(fā)去除Et2O，粗產(chǎn)物通過快速色譜法（洗脫劑：石油醚（沸點(diǎn)50-70℃）/乙酸乙酯，比例從5:1漸變至3:1）進(jìn)行純化。
參考文獻(xiàn)：
[1] Agricultural and Biological Chemistry, 1985, vol. 49, # 3, p. 719 - 724
[2] European Journal of Medicinal Chemistry, 2014, vol. 85, p. 621 - 628
[3] Australian Journal of Chemistry, 2005, vol. 58, # 7, p. 551 - 555
[4] European Journal of Medicinal Chemistry, 2018, vol. 155, p. 255 - 262
[5] Bioorganic and Medicinal Chemistry, 2006, vol. 14, # 13, p. 4402 - 4409
| 報(bào)價(jià)日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱 | CAS號(hào) | 包裝 | 價(jià)格 |
| 2026/03/03 | S4249 | 夫洛丙酮 Flopropione | 2295-58-1 | 50mg | 800.41元 |
| 2025/12/22 | T0887 | 2',4',6'-三羥基苯丙酮 2',4',6'-Trihydroxypropiophenone | 2295-58-1 | 1G | 110元 |
| 2025/12/22 | HY-100562 | 夫洛丙酮 Flopropione | 2295-58-1 | 100mg | 350元 |
常見問題列表
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5-HT 1A Receptor
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COMT
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Flopropione在低于其T (g)溫度下表現(xiàn)出無Lorentzian舒張。Flopropione在低于其T (g)溫度下比Nifedipine具有更高的分子流動(dòng)性。 Flopropione在整個(gè)溫度范圍表現(xiàn)出Arrhenius溫度依賴性，推斷高于T (g)時(shí)通過介電弛豫測(cè)量的tau（β）與低于T (g)時(shí)通過TAM/MDSC測(cè)量的tau（β）相一致。
The effect of Flopropione as an antispasmodic agent on the rate of passing a calculus from the urinary tract has been compared retrospectively with patients in whom passage was spontaneous. Flopropine has been shown, with statistical significance, to be superior to the control in cumulative passage rate after initiation of administration. Flopropine has been shown to exert a spasmolytic effect not only on smooth muscle of the gastrointestinal tract but also on smooth muscle of the pancreatobiliary and urinary systems.