24144-92-1

中文名稱 2,3',4,5'-四甲氧基二苯乙烯

英文名稱 TMS

CAS 24144-92-1

分子式 C18H20O4

分子量 300.35

MOL 文件 24144-92-1.mol

更新日期 2026/06/23 16:18:26

24144-92-1 結(jié)構(gòu)式

基本信息物理化學(xué)性質(zhì) 安全數(shù)據(jù) 圖譜信息 2,3',4,5'-四甲氧基二苯乙烯價(jià)格(試劑級(jí)) 常見問題列表

基本信息

中文別名

化合物TMS
5'-四甲氧基二苯乙烯
2,3',4,5'-四甲氧基二苯乙烯

英文別名

CS-961
SMB 00388
TMS, >=98%
5'-tetramethoxystilbene
3,5,2’,4’-Tetramethoxystilbene
2,3',4,5'-TETRAMETHOXYSTILBENE
(E)-2,3',4,5'-TETRAMETHOXYSTILBENE
TMS - Trans-2,3',4,5'-tetramethoxystilbene
(E)-1-(3,5-Dimethoxystyryl)-2,4-dimethoxybenzene
1-[2,(3,5-DIMETHOXYPHENYL)ETHENYL]-2,4-DIMETHOXYBENZENE

所屬類別

化學(xué)試劑：烯烴（環(huán)狀與無環(huán)狀）

物理化學(xué)性質(zhì)

熔點(diǎn)78-79 °C

沸點(diǎn)459.9±40.0 °C(Predicted)

密度1.117±0.06 g/cm3(Predicted)

儲(chǔ)存條件Sealed in dry,Store in freezer, under -20°C

溶解度DMF: 30 mg/ml; DMF:PBS (pH 7.2) (1:1): 500 μg/ml; DMSO: 20 mg/ml; Ethanol: 400 μg/ml

形態(tài)粉末

顏色Light yellow to yellow

安全數(shù)據(jù)

危險(xiǎn)性符號(hào)(GHS) 有害 (GHS07)

GHS07

警示詞警告

危險(xiǎn)性描述H302

防范說明P280-P305+P351+P338

圖譜信息

2,3',4,5'-四甲氧基二苯乙烯(24144-92-1)核磁圖(¹HNMR)

2,3',4,5'-四甲氧基二苯乙烯價(jià)格(試劑級(jí))

報(bào)價(jià)日期	產(chǎn)品編號(hào)	產(chǎn)品名稱	CAS號(hào)	包裝	價(jià)格
2026/06/05	HY-19340	2,3',4,5'-四甲氧基二苯乙烯 TMS	24144-92-1	5 mg	550元
2026/06/05	HY-19340	2,3',4,5'-四甲氧基二苯乙烯 TMS	24144-92-1	10 mM * 1 mL in DMSO	605元
2026/06/05	HY-19340	2,3',4,5'-四甲氧基二苯乙烯 TMS	24144-92-1	10 mg	880元

常見問題列表

生物活性

TMS ((E)-2,3',4,5'-tetramethoxystilbene) 是一種選擇性和競(jìng)爭(zhēng)性 CYP1B1 抑制劑，IC50 為 6 nM，Ki 值為 3 nM。TMS 對(duì) CYP1A1 (IC50=300 nM) 和 CYP1A2 (IC50=3.1 μM) 的抑制作用較小。TMS 是白藜蘆醇的甲基化衍生物，具有抗癌活性。

靶點(diǎn)

CYP1B1

6 nM (IC ₅₀ )

CYP1B1

3 nM (Ki)

CYP1A1

300 nM (IC ₅₀ )

CYP1A2

3.1 μM (IC ₅₀ )

體外研究

TMS, an analogue of resveratrol, is considered to be a potential cancer preventive agent since it is a potent inhibitor of CYP1B1. To assess survival of MCF-7 cells exposed to 1 μM benzo[a]pyrene (BP), 1 μM BP+1 μM TMS and 1 μM BP+4 μM TMS, cells ae incubated for up to 72 h without a media change. Luminescence units from exposed cells, expressed as a percentage of luminescence units from solvent (DMSO)-treated cells at the same time intervals. In all exposure groups, cell viability remains >90% for the first 24 h, but by 72 h, cell survival drops to 60-70%.

體內(nèi)研究

To determine the contribution of CYP1B1 in development of hypertension in spontaneously hypertensive rats (SHR), the effect of TMS is examined on in SHR and WKY rats. Systolic BP steadily increases in SHR from 4 weeks of age. Starting from 8 weeks of age, daily injections of TMS reduce systolic BP in SHR to levels observed at the beginning of the experiment (207±7 vs. 129±2 mmHg). Systolic BP is not altered in WKY injected with TMS or its vehicle (129±7 vs. 127±4 mmHg) .