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25843-45-2

中文名稱 偶氮甲烷
英文名稱 AZOXYMETHANE
CAS 25843-45-2
分子式 C2H6N2O
分子量 74.08
MOL 文件 25843-45-2.mol
更新日期 2024/05/28 16:04:18
25843-45-2 結(jié)構(gòu)式 25843-45-2 結(jié)構(gòu)式

基本信息

中文別名
偶氮甲烷
氧化偶氮基甲烷
AOM氧化偶氮甲烷
偶氮甲烷(AOM)
結(jié)腸癌造模誘導(dǎo)劑氧化偶氮甲烷
PERFEMIKER]氧化偶氮甲烷,95%
英文別名
AOM
AZOXYMETHANE
azoxy-methan
CH3N=N(→O)CH3
Methane, azoxy-
ONN-Azoxydimethane
Dimethyldiazene 1-oxide
Azoxymethane DISCONTINUED
1,2-Dimethyldiazene 1-oxide
(Z)-1,2-diMethyldiazene oxide

物理化學(xué)性質(zhì)

沸點(diǎn)97-99 °C(lit.)
密度0.991 g/mL at 25 °C(lit.)
折射率1.4368 (estimate)
閃點(diǎn)24 °C
儲(chǔ)存條件−20°C
溶解度Soluble in water, ethanol, and ether
形態(tài)Liquid
比重0.991
顏色Oil
主要應(yīng)用genomic analysis
InChIInChI=1S/C2H6N2O/c1-3-4(2)5/h1-2H3
InChIKeyDGAKHGXRMXWHBX-UHFFFAOYSA-N
SMILES[N+]([O-])(C)=NC
EPA化學(xué)物質(zhì)信息Azoxymethane (25843-45-2)

安全數(shù)據(jù)

危險(xiǎn)性符號(hào)(GHS)易燃 (GHS02)有毒 (GHS06)健康危害 (GHS08)
GHS02,GHS06,GHS08
警示詞危險(xiǎn)
危險(xiǎn)性描述H226-H300-H315-H319-H350
危險(xiǎn)品標(biāo)志T
危險(xiǎn)類別碼45-46-10-25-34-36/38
安全說(shuō)明53-26-36/37/39-45
危險(xiǎn)品運(yùn)輸編號(hào)UN 1992 3/PG 3
WGK Germany3
RTECS號(hào)PA2975000
存儲(chǔ)類別3 - Flammable liquids
危險(xiǎn)性類別Acute Tox. 2 Oral
Carc. 1B
Eye Irrit. 2
Flam. Liq. 3
Skin Irrit. 2
毒性mma-sat 13,600 mmol/L/20M CNREA8 38,4585,78

上下游產(chǎn)品信息

下游產(chǎn)品
頭孢呋辛
偶氮甲烷價(jià)格(試劑級(jí))
報(bào)價(jià)日期產(chǎn)品編號(hào)產(chǎn)品名稱CAS號(hào)包裝價(jià)格
2026/06/05HY-111375偶氮甲烷
Azoxymethane
25843-45-25mg(135mM * 500μL in Water)2656元
2026/06/05HY-111375偶氮甲烷
Azoxymethane
25843-45-210 mg (135 mM * 1 mL in Water)4650元
2025/05/22XW2584345201氧化偶氮甲烷
Azoxymethane
25843-45-2100mg22671元

常見(jiàn)問(wèn)題列表

生物活性
Azoxymethane 是一種結(jié)腸致癌物質(zhì),可導(dǎo)致 DNA 加合物的形成。
體外研究

Azoxymethane is a colon carcinogen which leads to the formation of DNA adducts. On an equal protein basis, hepatic microsomes are much more active than SI and colon microsomes in NADPH-dependent Azoxymethane bioactivation and N 7 -mG adduct formation. Hepatic microsomes show the highest activity in the hydroxylation of Azoxymethane, followed by SI and colon microsomes.

體內(nèi)研究

Regardless of the strain, the amounts of O 6 -mG and N 7 -mG produced by Azoxymethane are highest in the liver, followed by proximal and distal colons, which have similar levels, and then by duodenum, jejunum and ileum. Results indicate that the Azoxymethane-induced DNA adduct formation in the SI and colon does not depend on bioactivation by hepatic P450 enzymes. Irrespective of the mouse strain, no aberrant crypt foci (ACF) is detected in the colons of saline-treated mice; in contrast, colonic ACF is detected in all three strains of Azoxymethane-treated mice. The Azoxymethane-treated athymic mice have approximately an 11-fold lower tumor incidence than similarly treated WT animals.

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