26171-23-3

中文名稱(chēng) 托麥汀

英文名稱(chēng) Tolmetin

CAS 26171-23-3

分子式 C15H15NO3

MDL 編號(hào) MFCD00599595

分子量 257.28

MOL 文件 26171-23-3.mol

更新日期 2026/07/27 09:01:22

26171-23-3 結(jié)構(gòu)式

基本信息物理化學(xué)性質(zhì) 安全數(shù)據(jù) 圖譜信息托麥汀價(jià)格(試劑級(jí)) 常見(jiàn)問(wèn)題列表

基本信息

中文別名

甲苯酰吡咯乙酸
痛滅定
托麥汀
托美汀
2-[1-甲基-5-(4-甲基苯甲酰)吡咯-2-基]乙酸

英文別名

Tolmetin
Tolmetine
TOLMETINUM
2-[1-Methyl-5-(4-methylbenzoyl)-pyrrol-2-yl]acetic acid
1H-Pyrrole-2-acetic acid, 1-methyl-5-(4-methylbenzoyl)-
1-Methyl-5-p-toluoylpyrrole-2-acetic acid
5-[(p-Tolyl)carbonyl]-1-methylpyrrole-2-acetic acid
McN 2559
1-Methyl-5-(4-methylbenzoyl)-1H-pyrrole-2-acetic acid
1-Methyl-5-(p-toluoyl)-1H-pyrrole-2-acetic acid

所屬類(lèi)別

生物化工：激動(dòng)劑抑制劑

物理化學(xué)性質(zhì)

熔點(diǎn)156 °C

沸點(diǎn)400.53°C (rough estimate)

密度1.1391 (rough estimate)

折射率1.5200 (estimate)

儲(chǔ)存條件Sealed in dry,2-8°C

溶解度可溶于氯仿（少許）、甲醇（少許）

酸度系數(shù)(pKa)pKa 3.5(H2O t undefined I undefined) (Uncertain)

形態(tài)固體

顏色灰白色至淡黃色

水溶解性222 mg/L

InChIInChI=1S/C15H15NO3/c1-10-3-5-11(6-4-10)15(19)13-8-7-12(16(13)2)9-14(17)18/h3-8H,9H2,1-2H3,(H,17,18)

InChIKeyUPSPUYADGBWSHF-UHFFFAOYSA-N

SMILESN1(C)C(C(=O)C2=CC=C(C)C=C2)=CC=C1CC(O)=O

NIST化學(xué)物質(zhì)信息Tolmetin(26171-23-3)

EPA化學(xué)物質(zhì)信息1H-Pyrrole-2-acetic acid, 1-methyl-5-(4-methylbenzoyl)- (26171-23-3)

安全數(shù)據(jù)

危險(xiǎn)性符號(hào)(GHS) 有害 (GHS07)

GHS07

警示詞警告

危險(xiǎn)性描述H315-H302-H335-H319

防范說(shuō)明P264-P280-P305+P351+P338-P337+P313P-P264-P280-P302+P352-P321-P332+P313-P362-P264-P270-P301+P312-P330-P501

毒害物質(zhì)數(shù)據(jù)26171-23-3(Hazardous Substances Data)

圖譜信息

托麥汀(26171-23-3)核磁圖(¹HNMR)

托麥汀價(jià)格(試劑級(jí))

報(bào)價(jià)日期	產(chǎn)品編號(hào)	產(chǎn)品名稱(chēng)	CAS號(hào)	包裝	價(jià)格
2026/07/06	S4832	托麥汀 Tolmetin	26171-23-3	25mg	795.02元
2026/07/06	S4832	托麥汀 Tolmetin	26171-23-3	1g	3031.12元
2026/06/05	HY-B1799R	托麥汀 Tolmetin (Standard)	26171-23-3	5 mg	390元

常見(jiàn)問(wèn)題列表

生物活性

Tolmetin (Tolectin) 是一種非類(lèi)固醇的抗炎藥，屬于雜環(huán)乙酸衍生物類(lèi)，具有止痛和退熱作用。

靶點(diǎn)

Human COX-1

0.35 μM (IC ₅₀ )

Human COX-2

0.82 μM (IC ₅₀ )

體外研究

Tolmetin (0.25 mM) does not attenuate lipid peroxidation in rat brain homogenate. Tolmetin (0.25, 0.5, 0.75, 1 mM) shows radical scavenging properties but without superoxide anion generation in rat brain homogenat.
Tolmetin (0.001-100 μM) shows anticancer activity againts HT-29 colon cancer cell line in a dose-dependent manner.
Tolmetin (0-100 μM) shows no effect on osteoblast growth.

體內(nèi)研究

Tolmetin (30,100 mg/kg; gavage; single dose or twice daily for 3 and 14 days) shows maximal ulcerogenic effect 4 h after the single dose, while potently decreases after 3 and 14 days of repeated administration in male Wistar rats weighing 180-200 g. Tolmetin causes gastric lesions in 100 mg/kg.
Tolmetin (5 mg/kg twice a day for 5 days) pre-treatment considerably attenuates quinolinic acid (QA)-induced neurotoxicity.