27113-22-0
27113-22-0 結(jié)構(gòu)式
基本信息
姜酮酚價(jià)格
姜酮酚廠家
姜酮酚作用
非洲豆蔻醇
食品級(jí)姜酮酚
姜酮酚生產(chǎn)廠家
食品級(jí)姜酮酚廠家
5-去氧-姜辣醇
5-去氧-6-姜酚
PARADOL
5-Paradol
6-paradol
Ccris 8519
Brn 1984119
[6]-Gingerone
6-Paradol 98%
PARADOL PARADOL
Einecs 248-228-1
物理化學(xué)性質(zhì)
pharmaceutical
制備方法
53172-10-4
27113-22-0
在氮?dú)獗Ｗo(hù)下，向反應(yīng)燒瓶中加入16g金屬鈉、3.5g無(wú)水乙酸鈉和110g四氫呋喃，室溫?cái)嚢?。緩慢滴加?0g烯烴中間體和200g乙醇組成的溶液，滴加過(guò)程約2小時(shí)完成。隨后加熱回流反應(yīng)，通過(guò)薄層色譜（展開(kāi)劑比例為石油醚：二氯乙烷=3：2）監(jiān)測(cè)反應(yīng)進(jìn)程。待原料完全消失后，繼續(xù)反應(yīng)3.5小時(shí)。停止反應(yīng)，加入10g活性炭，繼續(xù)回流0.5小時(shí)。反應(yīng)混合物經(jīng)過(guò)濾后，減壓濃縮除去溶劑。殘余物用水洗滌，分層后脫水，得到淡黃色油狀產(chǎn)物。產(chǎn)物純度為98%，收率為94%。
參考文獻(xiàn)：
[1] Patent: CN106866393, 2017, A. Location in patent: Paragraph 0045; 0046; 0047; 0048
[2] Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1972, p. 3001 - 3006
常見(jiàn)問(wèn)題列表
2. 循環(huán)系統(tǒng)：6-姜酮酚可以降低血壓和血脂，減少動(dòng)脈粥樣硬化的發(fā)生，對(duì)心血管系統(tǒng)有保護(hù)作用。
3. 免疫系統(tǒng)：研究發(fā)現(xiàn)，6-姜酮酚可以增強(qiáng)機(jī)體的免疫功能，提高抗病能力，有助于預(yù)防和治療免疫系統(tǒng)相關(guān)的疾病。
4. 神經(jīng)系統(tǒng)：6-姜酮酚具有鎮(zhèn)靜、鎮(zhèn)痛和抗抑郁作用，可以改善神經(jīng)系統(tǒng)相關(guān)疾病的癥狀。
5-去氧-6-姜辣醇是有機(jī)合成中間體和醫(yī)藥中間體，主要用于實(shí)驗(yàn)室研發(fā)過(guò)程和化工醫(yī)藥合成過(guò)程中。
|
COX-2
|
Paradol ([6]-paradol) induces apoptosis in an oral squamous carcinoma cell line, KB, in a dose-dependent manner. Paradol induces apoptosis through a caspase-3-dependent mechanism.
Administration of Paradol (6-paradol) (10 mg/kg) clearly reduces the number of Iba1-positive cells 1 and 3 days after the challenge. Moreover, Paradol dramatically reduces the number of Iba1-postive cells in periischemic regions even after 3 days following M/R challenge. Paradol (6-paradol) exhibits the strongest anti-inflammatory effect of several paradol compounds in lipopolysaccharide-stimulated BV2 microglia derived from a mouse brain, including 2-, 4-, 6-, 8-, and 10-paradol. Furthermore, Paradol shows the strongest pungency of all of the known paradol analogues. Paradol also shows the highest contact time at the antiobesity site of action on the basis of the results shown for the absorption of the metabolites in this study.