2797-51-5
中文名稱
2-氨基-3-氯-1,4-萘醌
英文名稱
2-AMINO-3-CHLORO-1,4-NAPHTHOQUINONE
CAS
2797-51-5
EINECS 編號(hào)
220-529-2
分子式
C10H6ClNO2
MDL 編號(hào)
MFCD00001680
分子量
207.61
MOL 文件
2797-51-5.mol
更新日期
2023/03/20 19:41:19
2797-51-5 結(jié)構(gòu)式
基本信息
中文別名
2-氨基-3-氯-1,4-萘醌滅藻醌
英文別名
2-AMINO-3-CHLORO-1,4-NAPHTHOQUINONE2-AMINO-3-CHLORO-1,4-NAPHTOQUINONE
ACN
ASISCHEM T86788
MOGETON
QUINOCLAMIN
QUINOCLAMINE
TIMTEC-BB SBB008204
06k
06k-50w
06K-Quinone
1,4-Naphthoquinone, 2-Amino-3-chloro-
2-amino-3-chloro-4-naphthalenedione
2-amino-3-chloro-4-naphthoquinone
2-Amino-3-Chloronaphthoquinone
2-Chloro-3-amino-1,4-naphthoquinone
3-Chloro-2-amino-1,4-naphthoquinone
ACNQ
Mogeton G
Mogeton granule
所屬類別
分析化學(xué)：農(nóng)殘、獸藥及化肥類物理化學(xué)性質(zhì)
熔點(diǎn)198-200 °C
沸點(diǎn)310℃
密度1.49
折射率1.5790 (estimate)
閃點(diǎn)141℃
儲(chǔ)存條件0-6°C
溶解度DMSO: 250 mg/mL (1204.18 mM)
水溶解性不溶于水
酸度系數(shù)(pKa)0.70±0.20(Predicted)
形態(tài)粉末
顏色橙色
主要應(yīng)用agriculture
environmental
environmental
InChI1S/C10H6ClNO2/c11-7-8(12)10(14)6-4-2-1-3-5(6)9(7)13/h1-4H,12H2
InChIKeyOBLNWSCLAYSJJR-UHFFFAOYSA-N
SMILESNC1=C(Cl)C(=O)c2ccccc2C1=O
LogP2.120
CAS 數(shù)據(jù)庫(kù)2797-51-5(CAS DataBase Reference)
EPA化學(xué)物質(zhì)信息2-Amino-3-chloro-1,4-naphthoquinone (2797-51-5)
安全數(shù)據(jù)
警示詞警告
危險(xiǎn)性描述H302-H317-H319-H351-H361d-H373-H410
危險(xiǎn)品標(biāo)志T
危險(xiǎn)類別碼R36/37/38-R23-R22
安全說(shuō)明S45-S37/39-S26
危險(xiǎn)品運(yùn)輸編號(hào)UN2811 - class 6.1 - PG 3 - EHS - Toxic solids, organic, n.o.s., HI: all
WGK Germany3
RTECS號(hào)QL7350000
危險(xiǎn)等級(jí)6.1
海關(guān)編碼29223990
存儲(chǔ)類別11 - Combustible Solids
危險(xiǎn)性類別Acute Tox. 4 Oral
Aquatic Acute 1
Aquatic Chronic 1
Carc. 2
Eye Irrit. 2
Repr. 2
Skin Sens. 1A
STOT RE 2
Aquatic Acute 1
Aquatic Chronic 1
Carc. 2
Eye Irrit. 2
Repr. 2
Skin Sens. 1A
STOT RE 2
毒性LD50 oral in rat: 1360mg/kg
2797-51-5(安全特性,毒性,儲(chǔ)運(yùn))
儲(chǔ)運(yùn)特性
庫(kù)房通風(fēng)低溫干燥; 與食品原料分開(kāi)儲(chǔ)運(yùn)毒性分級(jí)
中毒急性毒性
口服- 大鼠 LD50: 1360 毫克/ 公斤; 口服- 小鼠 LD50: 1260 毫克/ 公斤可燃性危險(xiǎn)特性
燃燒產(chǎn)生有毒氮氧化物和氯化物氣體類別
農(nóng)藥滅火劑
干粉、泡沫、砂土知名試劑公司產(chǎn)品信息
Acros Organics
滅藻醌2-Amino-3-chloro-1,4-naphthoquinone(2797-51-5)
Sigma Aldrich
2797-51-5(sigmaaldrich)2-氨基-3-氯-1,4-萘醌價(jià)格(試劑級(jí))
| 報(bào)價(jià)日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱 | CAS號(hào) | 包裝 | 價(jià)格 |
| 2025/12/22 | HY-N4176 | 2-氨基-3-氯-1,4-萘醌 Ginkgolide K | 2797-51-5 | 1mg | 500元 |
| 2025/12/22 | HY-N4176 | 2-氨基-3-氯-1,4-萘醌 Ginkgolide K | 2797-51-5 | 5mg | 1400元 |
| 2025/12/22 | HY-N4176 | 2-氨基-3-氯-1,4-萘醌 Ginkgolide K | 2797-51-5 | 10mM * 1mLin DMSO | 1540元 |
常見(jiàn)問(wèn)題列表
生物活性
Quinoclamine 是一種萘醌衍生物，是一種 NF-κB 抑制劑。Quinoclamine 具有抗腫瘤活性。靶點(diǎn)
NF-κB
體外研究
Quinoclamine causes differentiation of U-937 cells into macrophage-like cells.
Quinoclamine inhibits NF-κB activities in HepG2 cells, with an IC
50
of 1.7 μM.
Quinoclamine (1-4 μM; 30 minutes ) suppresses endogenous NF-κB activity in HepG2 cells through the inhibition of IκB-α phosphorylation and p65 translocation.
Quinoclamine inhibits induced NF-κB activities in lung and breast cancer cell lines.
Quinoclamine affects the expression levels of genes involved in cell cycle or apoptosis.
Quinoclamine down-regulates the expressions of UDP glucuronosyltransferase genes involved in phase II drug metabolism.
Cell Viability Assay
| Cell Line: | HepG2 cells |
| Concentration: | 1 μM, 2 μM, 4 μM, 8 μM, 16 μM, 32 μM, 64 μM |
| Incubation Time: | 24 hours |
| Result: | Inhibited NF-κB activities in HepG2 cells. |
Western Blot Analysis
| Cell Line: | HepG2 cells |
| Concentration: | 0 μM, 1 μM, 2 μM, 4 μM |
| Incubation Time: | 30 minutes |
| Result: | Inhibited IκB-α phosphorylation and p65 translocation in HepG2 cells. |