一二三四区视频,亚洲少妇熟女色,日本久热无码视频网,欧美国产日韩大尺度,亚洲a视频,久久少妇一区二区,日韩999无码视频,刺激久久久久久久,啊啊啊啊不要啊在线

返回ChemicalBook首頁(yè)>CAS數(shù)據(jù)庫(kù)列表>28755-03-5

28755-03-5

中文名稱 2-氯-1-(1H-吲哚-3-基)-乙酮
英文名稱 Ethanone, 2-chloro-1-(3-indolyl)-
CAS 28755-03-5
分子式 C10H8ClNO
分子量 193.63
MOL 文件 28755-03-5.mol
28755-03-5 結(jié)構(gòu)式 28755-03-5 結(jié)構(gòu)式

基本信息

中文別名
3-氯乙?;胚?BR>2-氯-1-(3-吲哚基)-乙酮
乙酮,2-氯-1H-吲哚-1-基-
乙酮,2-氯-1-(3-吲哚基)-
2-氯-1-(1H-吲哚-3-基)-乙酮
乙酮,2-氯-1-(1H-吲哚-3-基)-
英文別名
3CAI
3CAI >=95% (HPLC)
3-chloroacetylindole
Akt Inhibitor XIX, 3CAI
Chloromethyl indol-3-yl ketone
3-(Chloroacetyl)-1H-indole 95%
2-Chloro-1-(3-Indolyl)-Ethanone
Ethanone, 2-chloro-1-(3-indolyl)-
Ethanone, 2-chloro-1H-indol-1-yl-
Ethanone, 2-chloro-1-(1H-indol-3-yl)-

物理化學(xué)性質(zhì)

熔點(diǎn)212-214 °C(Solv: ethyl ether (60-29-7))
沸點(diǎn)379.1±17.0 °C(Predicted)
密度1.337±0.06 g/cm3(Predicted)
儲(chǔ)存條件Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
溶解度DMSO:可溶,5mg/mL,澄清
酸度系數(shù)(pKa)15.08±0.30(Predicted)
形態(tài)粉末
顏色黃色到棕色
InChI1S/C10H8ClNO/c11-5-10(13)8-6-12-9-4-2-1-3-7(8)9/h1-4,6,12H,5H2
InChIKeyLLZQFAXTCYDVTR-UHFFFAOYSA-N

安全數(shù)據(jù)

危險(xiǎn)性符號(hào)(GHS)有害 (GHS07)
GHS07
警示詞警告
危險(xiǎn)性描述H302-H319
防范說(shuō)明P305+P351+P338
危險(xiǎn)品標(biāo)志Xn
危險(xiǎn)類別碼22-36
安全說(shuō)明26
WGK Germany3
海關(guān)編碼2933998090
存儲(chǔ)類別11 - Combustible Solids
2-氯-1-(1H-吲哚-3-基)-乙酮價(jià)格(試劑級(jí))
報(bào)價(jià)日期產(chǎn)品編號(hào)產(chǎn)品名稱CAS號(hào)包裝價(jià)格
2025/12/22HY-166662-氯-1-(1H-吲哚-3-基)-乙酮
3CAI
28755-03-51 mg261元
2025/12/22HY-166662-氯-1-(1H-吲哚-3-基)-乙酮
3CAI
28755-03-510mM * 1mLin DMSO556元
2025/12/22HY-166662-氯-1-(1H-吲哚-3-基)-乙酮
3CAI
28755-03-55mg580元

常見(jiàn)問(wèn)題列表

生物活性
3CAI 是一種有效的特異性 AKT1 和 AKT2 抑制劑。
靶點(diǎn)

Akt1

Akt2

體外研究

3CAI is a potential inhibitor of AKT. Based on these screening data, the effect of 3CAI on the kinase activities of AKT1, MEK1, JNK1, ERK1 and TOPK is tested using in vitro kinase assays. The results show that 3CAI (1 μM) suppresses only AKT1 kinase activity and the other kinases tested are not affected by 3CAI. 3CAI is a much more potent AKT1 inhibitor than PI3K (60% inhibition at 1 vs 10 μM, respectively). 3CAI substantially suppresses AKT1 activity as well as AKT2 activity in a dose dependent manner. 3CAI inhibits down-stream targets of AKT and induces apoptosis. AKT-mediated phosphorlyation site of mTOR (Ser2448) and GSK3β (Ser9) are substantially decreased by 3CAI in a time-dependent manner. Furthermore, pro-apoptotic marker proteins p53 and p21 are also upregulated by 3CAI after 12 or 24 h of treatment. HCT116 and HT29 colon cancer cells are seeded on 6 cm dishes in 1% FBS/McCoy's 5A (HCT116) with 3CAI (4 μM), I3C or the AKT inhibitor and then incubated for 4 days. Results show that the number of apoptotic cells is significantly increased by 3CAI in HCT116 and HT29 colon cancer cells compared with untreated control cells.

體內(nèi)研究

To examine the antitumor activity of 3CAI in vivo, HCT116 cancer cells are injected into the right flank of individual athymic nude mice. Mice are orally administered 3CAI at 20 or 30 mg/kg, I3C at 100 mg/kg, or vehicle 5 times a week for 21 days. Treatment of mice with 30 mg/kg of 3CAI significantly suppresses HCT116 tumor growth by 50% relative to the vehicle-treated group (p<0.05). Remarkably, mice seem to tolerate treatment with these doses of 3CAI without overt signs of toxicity or significant loss of body weight compared with vehicle-treated group. Expression of these AKT-target proteins is strongly suppressed by 30 mg/kg of 3CAI in tumor tissues.

"28755-03-5" 相關(guān)產(chǎn)品信息
松阳县| 南郑县| 湖口县| 乐都县| 兴化市| 玉林市| 安岳县| 门头沟区| 宝兴县| 泊头市| 镇坪县| 旺苍县| 兖州市| 孝昌县| 利辛县| 连平县| 沁阳市| 呼和浩特市| 南宫市| 奉节县| 林西县| 东乡族自治县| 郸城县| 孟村| 建平县| 西乌| 青阳县| 宜君县| 韶关市| 青川县| 阿拉善左旗| 广元市| 望奎县| 岑巩县| 无棣县| 海林市| 万山特区| 海兴县| 新龙县| 东阳市| 郑州市|