291758-32-2
中文名稱
NΩ-羥基或- L -精氨酸鹽酸鹽
英文名稱
N-OMEGA-HYDROXYL-NOR-L-ARGININE, DIHYDROCHLORIDE
CAS
291758-32-2
分子式
C5H12N4O3
分子量
176.174
MOL 文件
291758-32-2.mol
更新日期
2026/07/16 12:18:37
291758-32-2 結(jié)構(gòu)式
基本信息
中文別名
NΩ-羥基或- L -精氨酸鹽酸鹽(S)-2-氨基-4-(3-羥基胍基)丁酸二鹽酸鹽
英文別名
nor-NOHA HClNω-Hydroxy-nor-L-Arginine Dihydrochloride
N-OMEGA-HYDROXYL-NOR-L-ARGININE, DIHYDROCHLORIDE
(2S)-2-AMino-4-[[(hydroxyaMino)iMinoMethyl]aMino]butanoic Acid
(S)-2-Amino-4-(3-hydroxyguanidino)butanoic acid dihydrochloride
應(yīng)用領(lǐng)域
用途一
Nω-Hydroxy-nor-L-Arginine Dihydrochloride is a reversible, competitive inhibitor of arginase. It is neither a substrate nor an inhibitor for iNOS and it appears as a useful tool to study the interplays between arginase and NOS. Was found to be much more potent than NOHA and homo-NOHA to inhibit the rat liver arginase-dependent hydrolysis of L-arg.常見問題列表
概述
NΩ-羥基或- L -精氨酸鹽酸鹽 是一種選擇性的，可逆的 arginase 抑制劑。nor-NOHA dihydrochloride 在缺氧條件誘導(dǎo) ARG2 表達(dá)細(xì)胞的 apoptosis。nor-NOHA dihydrochloride 有抗白血病的活性。nor-NOHA dihydrochloride 可用于研究內(nèi)皮功能障礙、免疫抑制及代謝。