303727-31-3

中文名稱 4-(4-氯-3-羥基苯基)-2-苯基-5-(吡啶-4-基)-1H-咪唑

英文名稱 2-(Phenyl)-4-(3-hydroxy-4-chlorophenyl)-5-(4-pyridyl)-1H-imidazole

CAS 303727-31-3

分子式 C20H14ClN3O

分子量 347.8

MOL 文件 303727-31-3.mol

更新日期 2024/06/17 17:25:38

303727-31-3 結(jié)構(gòu)式

基本信息物理化學(xué)性質(zhì) 安全數(shù)據(jù) 圖譜信息 4-(4-氯-3-羥基苯基)-2-苯基-5-(吡啶-4-基)-1H-咪唑價格(試劑級) 常見問題列表

基本信息

中文別名

RAF激酶抑制劑(L-779450)
2-氯-5-(2-苯基-5-(吡啶-4-基)-1H-咪唑-4-基)苯酚
4-(4-氯-3-羥基苯基)-2-苯基-5-(吡啶-4-基)-1H-咪唑

英文別名

450
L-779
CS-1697
L-779450
Raf Kinase Inhibitor IV
2-Chloro-5-[2-Phenyl-5-(4-pyridinyl)-1H-imidazol-4-yl]phenol
2-chloro-5-[2-phenyl-4-(4-pyridinyl)-1H-imidazol-5-yl]phenol
2-chloro-5-(2-phenyl-4-(pyridin-4-yl)-1H-imidazol-5-yl)phenol
2-Chloro-5-(2-phenyl-5-(pyridin-4-yl)-1H-iMidazol-4-yl)phenol
Phenol, 2-chloro-5-[2-phenyl-4-(4-pyridinyl)-1H-iMidazol-5-yl]-

所屬類別

醫(yī)藥中間體：羥基吡啶

物理化學(xué)性質(zhì)

沸點(diǎn)579.8±50.0 °C(Predicted)

密度1.335±0.06 g/cm3(Predicted)

儲存條件Sealed in dry,2-8°C

溶解度DMSO:44.67(Max Conc. mg/mL);128.44(Max Conc. mM)
DMF:30.0(Max Conc. mg/mL);86.26(Max Conc. mM)
DMF:PBS (pH 7.2) (1:7):0.12(Max Conc. mg/mL);0.35(Max Conc. mM)
Ethanol:2.0(Max Conc. mg/mL);5.75(Max Conc. mM)

酸度系數(shù)(pKa)8.09±0.10(Predicted)

形態(tài)粉末

顏色Light yellow to yellow

InChI1S/C20H14ClN3O/c21-16-7-6-15(12-17(16)25)19-18(13-8-10-22-11-9-13)23-20(24-19)14-4-2-1-3-5-14/h1-12,25H,(H,23,24)

InChIKeyWXJLXRNWMLWVFB-UHFFFAOYSA-N

SMILESClC(C(O)=C1)=CC=C1C(N=C(C2=CC=CC=C2)N3)=C3C4=CC=NC=C4

安全數(shù)據(jù)

危險性符號(GHS) 有毒 (GHS06)

GHS06

警示詞危險

危險性描述H301-H315-H319-H335

防范說明P280-P301+P310+P330-P304+P340+P312-P305+P351+P338-P337+P313

WGK GermanyWGK 3

海關(guān)編碼2933399990

存儲類別6.1C - Combustible acute toxic Cat.3
toxic compounds or compounds which causing chronic effects

圖譜信息

4-(4-氯-3-羥基苯基)-2-苯基-5-(吡啶-4-基)-1H-咪唑(303727-31-3)核磁圖(¹HNMR)

4-(4-氯-3-羥基苯基)-2-苯基-5-(吡啶-4-基)-1H-咪唑價格(試劑級)

報價日期	產(chǎn)品編號	產(chǎn)品名稱	CAS號	包裝	價格
2026/06/05	HY-12787	4-(4-氯-3-羥基苯基)-2-苯基-5-(吡啶-4-基)-1H-咪唑 L-779450	303727-31-3	5mg	650元
2026/06/05	HY-12787	4-(4-氯-3-羥基苯基)-2-苯基-5-(吡啶-4-基)-1H-咪唑 L-779450	303727-31-3	10mM * 1mLin DMSO	715元
2026/06/05	HY-12787	4-(4-氯-3-羥基苯基)-2-苯基-5-(吡啶-4-基)-1H-咪唑 L-779450	303727-31-3	10mg	1050元

常見問題列表

生物活性

L-779450是一種高效、低納摩爾的B-raf抑制劑，IC50為10 nM，Kd為2.4 nM。

靶點(diǎn)

Target	Value
B-Raf (Cell-free assay)	2.4 nM(Kd)
B-Raf (Cell-free assay)	10 nM

體外研究

L-779450 (L-779,450) shows a high degree of specificity towards Raf. The only other tested kinase inhibited is p38MAPK, which has a kinase domain structurally related to Raf. L-779450 inhibits anchorage-independent growth of human tumor lines at doses ranging from 0.3 to 2?μM. The effects of L-779450 (L-779,450) on TRAIL sensitivity are investigated here in melanoma cell lines with high TRAIL sensitivity (A-375 and SK-Mel-147), moderate sensitivity (Mel-HO, SK-Mel-13, and SK-Mel-28), and permanent resistance (MeWo, Mel-2a, and SK-Mel-103), as well as in TRAIL-selected cell lines with acquired resistance (A-375-TS and Mel-HO-TS). Despite only moderate direct effects of L-779450 on apoptosis, it strongly enhances TRAIL-induced apoptosis in sensitive melanoma cells and overrules TRAIL resistance in Mel-2a, SK-Mel-103, A-375-TS, and Mel-HO-TS. At 24?hours, 16-35% apoptosis induction is obtained.