306959-01-3
中文名稱(chēng)
N-(1,5-二甲基-3-氧代-2-苯基-2,3-二氫-1H-吡唑-4-基)-3-甲基-1-苯基-1H-噻吩并[2,3-C]吡唑-5-甲酰胺
英文名稱(chēng)
N-(1,5-dimethyl-3-oxo-2-phenylpyrazol-4-yl)-3-methyl-1-phenylthieno[2,3-c]pyrazole-5-carboxamide
CAS
306959-01-3
分子式
C24H21N5O2S
分子量
443.52
MOL 文件
306959-01-3.mol
更新日期
2026/02/12 14:22:48
306959-01-3 結(jié)構(gòu)式
基本信息
中文別名
化合物MYLS22N-(1,5-二甲基-3-氧代-2-苯基-2,3-二氫-1H-吡唑-4-基)-3-甲基-1-苯基-1H-噻吩并[2,3-C]吡唑-5-甲酰胺
英文別名
MYLS22N-(1,5-dimethyl-3-oxo-2-phenylpyrazol-4-yl)-3-methyl-1-phenylthieno[2,3-c]pyrazole-5-carboxamide
N-(1,5-Dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)-3-methyl-1-phenyl-1H-thieno[2,3-c]pyrazole-5-carboxamide
1H-Thieno[2,3-c]pyrazole-5-carboxamide, N-(2,3-dihydro-1,5-dimethyl-3-oxo-2-phenyl-1H-pyrazol-4-yl)-3-methyl-1-phenyl-
物理化學(xué)性質(zhì)
儲(chǔ)存條件-20°C儲(chǔ)存
溶解度DMSO: 83.33 mg/mL (187.88 mM)
形態(tài)Solid
顏色Off-white to yellow
常見(jiàn)問(wèn)題列表
生物活性
MYLS22 是首創(chuàng)的，選擇性視神經(jīng)萎縮 1 (OPA1) 抑制劑。MYLS22 可以靶向內(nèi)皮細(xì)胞 OPA1 減少腫瘤的生長(zhǎng)，通過(guò)影響 NFkB 活性和血管生成基因表達(dá)抑制血管生成。靶點(diǎn)
OPA1
體內(nèi)研究
MYLS22 (10 mg/kg/die; peritumoral injection; every 2 days for 14 days) causes the tumor growth curtailed mice.
| Animal Model: | 6-week-old C57BL6/J mice with B16F10 melanomas |
| Dosage: | 10 mg/kg/die |
| Administration: | Peritumoral injection; every 2 days for 14 days |
| Result: | Caused the tumor growth curtailed. |