312-45-8
中文名稱
半膽堿基-3
英文名稱
HEMICHOLINIUM-3
CAS
312-45-8
分子式
C24H34N2O4.2Br
分子量
574.351
MOL 文件
312-45-8.mol
更新日期
2026/07/20 08:35:52
312-45-8 結(jié)構(gòu)式
基本信息
中文別名
半膽堿基-3 英文別名
hc-3Dibromide
hemicholine
hemicholiniumbromide
hemicholinium-3bromide
hemicholiniumdibromide
hemicholinium-3dibromide
2,2'-(4,4'-biphenylene)bis(2-hydroxy-4,4-dimethylmorpholinium) dibromide
2,2’-(4,4’-biphenylylene)bis(2-hydroxy-4,4-dimethyl-morpholiniudibromide
2,2’-(1,1’-biphenyl)-4,4’-diylbis(2-hydroxy-4,4-dimethyl-morpholinium)dibrom
物理化學(xué)性質(zhì)
熔點(diǎn)180°; mp 226- 228° (dec)
儲存條件-20°C儲存
溶解度ethanol: 1.3 mg/mL
形態(tài)solid
顏色white
水溶解性Water : 33.33 mg/mL (58.03 mM; Need ultrasonic)
Merck13,4660
BRN5704458
InChI1S/C24H34N2O4.2BrH/c1-25(2)13-15-29-23(27,17-25)21-9-5-19(6-10-21)20-7-11-22(12-8-20)24(28)18-26(3,4)14-16-30-24;;/h5-12,27-28H,13-18H2,1-4H3;2*1H/q+2;;/p-2
InChIKeyOPYKHUMNFAMIBL-UHFFFAOYSA-L
SMILES[Br-].[Br-].C[N+]1(C)CCOC(O)(C1)c2ccc(cc2)-c3ccc(cc3)C4(O)C[N+](C)(C)CCO4
安全數(shù)據(jù)
警示詞危險(xiǎn)
危險(xiǎn)性描述H301+H311+H331-H315-H319-H335
危險(xiǎn)品標(biāo)志T
危險(xiǎn)類別碼23/24/25-36/37/38
安全說明26-36/37/39-45
危險(xiǎn)品運(yùn)輸編號UN 2811 6.1/PG 2
WGK Germany3
RTECS號QF2450000
TSCATSCA listed
危險(xiǎn)等級6.1(b)
包裝類別III
存儲類別6.1A - Combustible acute toxic Cat. 1 and 2
very toxic hazardous materials
very toxic hazardous materials
危險(xiǎn)性類別Acute Tox. 3 Dermal
Acute Tox. 3 Inhalation
Acute Tox. 3 Oral
Eye Irrit. 2
Skin Irrit. 2
STOT SE 3
Acute Tox. 3 Inhalation
Acute Tox. 3 Oral
Eye Irrit. 2
Skin Irrit. 2
STOT SE 3
毒性LD50 i.p. in female mice: 0.048-0.082 mg/kg (DiAugustine, Haarstad)
常見問題列表
概述
半膽堿基-3 是一種競爭性的高親和力膽堿轉(zhuǎn)運(yùn)蛋白 (HACU) 抑制劑，Ki 值為 25 nM。Hemicholinium 3抑制乙酰膽堿 (ACh)的合成和釋放，用作一種神經(jīng)肌肉阻滯劑。Hemicholinium 3 抑制Epibatidine誘發(fā)的收縮和 [3H] 乙酰膽堿釋放，IC50 分別為 897 nM 和 693 nM。