319-89-1
319-89-1 結(jié)構(gòu)式
基本信息
四羥基苯醌
2,3,5,6-四羥基-2,5-環(huán)已二烯-1,4-二酮
四羥基醌
四氧醌
四羥苯醌
TETRAHYDROXY-1,4-BENZOQUINONE
TETRAHYDROXY-1,4-QUINONE
TETRAHYDROXY BENZOQUINONE
TETRAHYDROXY-P-BENZOQUINONE
TETRAHYDROXYQUINONE
TETRAHYDROXYQUINONE, INDICATOR ''A''
TETRAHYDROXYQUINONE, INDICATOR ''B''
TETROQUINONE
2,3,5,6-Tetrahydroxy-2,5-cyclohexadien-1,4-dione
2,3,5,6-tetrahydroxy-2,5-cyclohexadiene-1,4-dione
2,3,5,6-Tetrahydroxybenzo-1,4-quinone
2,3,5,6-Tetrahydroxy-p-Benzoquinone
2,5-Cyclohexadiene-1,4-dione, 2,3,5,6-tetrahydroxy-
4-dione,2,3,5,6-tetrahydroxy-5-cyclohexadiene-1
HPEK-1
Kelox
NSC-112931
p-Benzoquinone, 2,3,5,6-tetrahydroxy-
Terasin
物理化學(xué)性質(zhì)
安全數(shù)據(jù)
常見問題列表
（1）按照重量份稱取各原料；
（2）將鈦合金、鋁合金、鎳合金、錫、銅、釹、鈮、銦、鎘、碳化硅、二氧化硅、熱穩(wěn)定劑加入坩堝電阻爐，抽真空，真空燒結(jié)，燒結(jié)溫度為900-960℃，燒結(jié)時(shí)間為2.5-4小時(shí)，得到真空燒結(jié)混合物；
（3）再將真空燒結(jié)混合物在惰性氣體中冷卻至350-380℃，然后注入三輥混煉機(jī)內(nèi)攪拌密煉30-60分鐘，密煉溫度為450℃，并依次加入醋酸纖維、聚砜、聚乙烯吡啶、四羥基苯醌、乙酸異丙烯酯,攪拌速度為500-800轉(zhuǎn)/分鐘；
（4）往步驟（3）得到的混合物中加入間硫甲酚、對(duì)氨基甲苯鄰磺酰苯胺、變性劑，攪拌均勻后加壓至2-5MPa,攪拌速度為400-800轉(zhuǎn)/分鐘，攪拌溫度為450℃，保溫?cái)嚢?小時(shí)；
（5）將步驟（4）得到的混合物直接注入模具壓制成型，將成型后的材料直接放入-30℃的低溫箱中冷卻20-30分鐘；
（6）將低溫冷卻后的成型物料放入惰性氣體保存箱，冷卻至室溫，得到成品。
其有益效果為：本發(fā)明的輕質(zhì)高強(qiáng)度復(fù)合金屬材料以鈦合金、鋁合金、鎳合金、錫、銅、釹、鈮、銦、鎘、碳化硅、二氧化硅為主要成分，通過加入醋酸纖維、聚砜、聚乙烯吡啶、四羥基苯醌、乙酸異丙烯酯、間硫甲酚、對(duì)氨基甲苯鄰磺酰苯胺、變性劑、熱穩(wěn)定劑，輔以真空燒結(jié)、高溫密煉、加壓攪拌、壓模冷卻等工藝，使得制備而成的 輕質(zhì)高強(qiáng)度復(fù)合金屬材料，其質(zhì)量輕、強(qiáng)度高，能夠滿足行業(yè)的要求，具有較好的應(yīng)用前景。
Tetrahydroxyquinone (100-500 μM; 24 hours; HL60 cells) treatment shows cytotoxic for HL60 leukaemia cells by total protein content (IC
50
of 20 μM), phosphatase activity (IC
50
of 40 μM), or by MTT assay (IC
50
of 45 μM). Tetrahydroxyquinone is an efficient inducer of ROS production in HL60 leukaemia cells.
Tetrahydroxyquinone efficiently activates caspase 3 in concentration in excess of 25 μM, stimulates DNA fragmentation at the same concentration and provoke phosphatidylserine exposure.
Tetrahydroxyquinone induces the release of cytochrome c from the mitochondria at concentration as low as 25 μM. Tetrahydroxyquinone treatment also causes increase of phosphorylation of Ser473 in protein kinase B (the Bad kinase for Ser112).
Cell Viability Assay
| Cell Line: | HL60 leukaemia cells |
| Concentration: | 100 μM, 200 μM, 300 μM, 400 μM, 500 μM |
| Incubation Time: | 24 hours |
| Result: | Showed cytotoxic for HL60 leukaemia cells. |