32233-40-2
中文名稱(chēng)
(-)-6beta-羥甲基-7alpha-羥基-順式-2-氧雜雙環(huán)[3.3.0]辛-3-酮
英文名稱(chēng)
(-)-Corey lactone diol
CAS
32233-40-2
分子式
C8H12O4
MDL 編號(hào)
MFCD00075234
分子量
172.18
MOL 文件
32233-40-2.mol
更新日期
2026/06/01 19:16:31
32233-40-2 結(jié)構(gòu)式
基本信息
中文別名
(-)-6beta-羥甲基-7alpha-羥基-順式-2-氧雜雙環(huán)[3.3.0]辛-3-酮(3aR,4S,5R,6aS)-(-)-六氫-5-羥基-4-羥甲基-2H-環(huán)戊并[b]呋喃-2-酮
科立內(nèi)脂二醇
考寧內(nèi)酯二醇(科爾內(nèi)酯二醇)
英文別名
(3AR,4S,5R,6AS)-(-)-HEXAHYDRO-5-HYDROXY-4-(HYDROXYMETHYL)-2H-CYCLOPENT A[B]FURAN-2-ONE(3AR,4S,5R,6AS)-HEXAHYDRO-5-HYDROXY-4-(HYDROXYMETHYL)-2H-CYCLOPENTA[B]FURAN-2-ONE
(-)-6BETA-HYDROXYMETHYL-7ALPHA-HYDROXY-CIS-2-OXABICYCLO[3.3.0]OCTAN-3-ONE
(-)-COREY LACTONE
COREY LACTONE DIOL
(3AR,4S,5R,6AS)-(-)-HEXAHYDRO-5-HYDROXY- 4-HOCH2-2H-CYCLOPENTA(B)FURAN-2-ONE, 98%
Hexahydro-5-hydroxy-4-(hydroxymethyl)-2H-cyclopenta[b]furan-2-one.
(-)-COREY DIOL (COREY LACTONE)
(-)-6beta-Hydroxymethyl-7alpha-hydroxy-cis-2-oxabicyclo[3.3.0]octan-3-one
(-)-Corey lactone diol
(-)-COREY LACTONE DIOL,98%
(3AR,4S,5R,6AS)-(-)-HEXAHYDRO-5-HYDROXY-4--2H-CYCLOPENTA(B)FURAN-2-ONE,
(1R)-2β-(Hydroxymethyl)-3α,5α-dihydroxycyclopentane-1α-acetic acid 1,5-lactone
(1S,5R,6S,7R)-7-Hydroxy-6-hydroxymethyl-2-oxabicyclo[3.3.0]octan-3-one
(3aβ,4S,6aβ)-4β-(Hydroxymethyl)-5α-hydroxyhexahydro-2H-cyclopenta[b]furan-2-one
所屬類(lèi)別
分析化學(xué)：藥典標(biāo)準(zhǔn)品和雜質(zhì)標(biāo)準(zhǔn)品物理化學(xué)性質(zhì)
熔點(diǎn)117-119 °C(lit.)
沸點(diǎn)262.49°C (rough estimate)
密度1.2104 (rough estimate)
折射率1.4455 (estimate)
儲(chǔ)存條件-20°C
溶解度可溶于DMSO（少許）、甲醇（少許）
酸度系數(shù)(pKa)14.36±0.40(Predicted)
形態(tài)結(jié)晶粉末或晶體
顏色白色至米棕色
旋光度 (Optical Rotation)[α]20/D 44°, c = 1.4 in methanol
InChIInChI=1S/C8H12O4/c9-3-5-4-1-8(11)12-7(4)2-6(5)10/h4-7,9-10H,1-3H2/t4-,5-,6-,7+/m1/s1
InChIKeyVYTZWRCSPHQSFX-GBNDHIKLSA-N
SMILESO1C(=O)C[C@]2([H])[C@@H](CO)[C@H](O)C[C@]12[H]
CAS 數(shù)據(jù)庫(kù)32233-40-2(CAS DataBase Reference)
安全數(shù)據(jù)
警示詞警告
危險(xiǎn)性描述H302-H315-H319-H335
防范說(shuō)明P261-P305+P351+P338
安全說(shuō)明S24/25
WGK Germany3
REACH 注冊(cè)登記Active
海關(guān)編碼29322090
存儲(chǔ)類(lèi)別11 - Combustible Solids
常見(jiàn)問(wèn)題列表
應(yīng)用
科立內(nèi)脂二醇是伊洛前列素(I267300)的中間體，對(duì)內(nèi)酰胺酶具有抑制活性。伊洛前列素(I267300)是一種合成的前列環(huán)素(PGI2)類(lèi)似物，用于治療肺動(dòng)脈高壓(PAH)、硬皮病、雷諾現(xiàn)象和缺血。
用途
科立內(nèi)脂二醇用作前列腺素類(lèi)原料藥、醫(yī)藥合成中間體等。生物活性
(-)-Corey lactone diol 是 corey aldehyde 的還原形式?；瘜W(xué)合成中的砌塊。知名試劑公司產(chǎn)品信息
Acros Organics
(-)-6beta-Hydroxymethyl-7alpha-hydroxy-cis-2-oxabicyclo[3.3.0]octan-3-one, 98%(32233-40-2)Sigma Aldrich
32233-40-2(sigmaaldrich)科立內(nèi)脂二醇價(jià)格(試劑級(jí))
| 報(bào)價(jià)日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱(chēng) | CAS號(hào) | 包裝 | 價(jià)格 |
| 2026/03/03 | H56119 | (3aR,4S,5R,6aS)-(-)-六氫化-5-羥基-4-羥基甲基-2H-環(huán)戊烷[b]呋喃-2-酮, 98% (3aR,4S,5R,6aS)-(-)-Hexahydro-5-hydroxy-4-hydroxymethyl-2H-cyclopenta[b]furan-2-one, 98% | 32233-40-2 | 250mg | 389元 |
| 2025/12/22 | H1418 | (-)-科里內(nèi)酯二醇 (-)-Corey Lactone Diol | 32233-40-2 | 200mg | 170元 |
| 2025/12/22 | H1418 | (-)-科里內(nèi)酯二醇 (-)-Corey Lactone Diol | 32233-40-2 | 1g | 720元 |