325850-81-5
中文名稱
GRI977143; GRI-977143
英文名稱
2-[3-(1,3-Dioxo-1H,3H-benzo[de]isoquinolin-2-yl)-propylsulfanyl]-benzoic acid
CAS
325850-81-5
分子式
C22H17NO4S
分子量
391.44
MOL 文件
325850-81-5.mol
更新日期
2026/02/27 17:00:22
325850-81-5 結(jié)構(gòu)式
基本信息
中文別名
2-[3-(1,3-二氧代-1H,3H-苯并[DE]異喹啉-2-基)-丙基磺?；鵠-苯甲酸 英文別名
GRI977143GRI977143
GRI-977143
2-[[3-(1,3-Dioxo-1H-benz[de]isoquinolin-2(3H)-yl)propyl]thio]-benzoic acid
2-((3-(1,3-Dioxo-(1H)benzo[de]isoquinolin-2(3H)-yl)propyl)thio)benzoic Acid
Benzoic acid, 2-[[3-(1,3-dioxo-1H-benz[de]isoquinolin-2(3H)-yl)propyl]thio]-
2-[3-(1,3-Dioxo-1H,3H-benzo[de]isoquinolin-2-yl)-propylsulfanyl]-benzoic acid
物理化學(xué)性質(zhì)
儲(chǔ)存條件2-8°C
溶解度DMSO：可溶10mg/mL，澄清
形態(tài)粉末
顏色白色至淺棕色
InChI1S/C22H17NO4S/c24-20-16-9-3-6-14-7-4-10-17(19(14)16)21(25)23(20)12-5-13-28-18-11-2-1-8-15(18)22(26)27/h1-4,6-11H,5,12-13H2,(H,26,27)
InChIKeyGMVZUCHUOYUMLL-UHFFFAOYSA-N
SMILESS(CCC[n]2[c](c3c4c([c]2=O)cccc4ccc3)=O)c1c(cccc1)C(=O)O
安全數(shù)據(jù)
警示詞警告
危險(xiǎn)性描述H302-H410
防范說(shuō)明P264-P270-P273-P301+P312-P391-P501
危險(xiǎn)品標(biāo)志Xn,N
危險(xiǎn)類別碼22-43-50/53
安全說(shuō)明36/37-60-61
危險(xiǎn)品運(yùn)輸編號(hào)UN 3077 9 / PGIII
WGK Germany3
存儲(chǔ)類別11 - Combustible Solids
危險(xiǎn)性類別Acute Tox. 4 Oral
Aquatic Acute 1
Aquatic Chronic 1
Aquatic Acute 1
Aquatic Chronic 1
GRI977143; GRI-977143價(jià)格(試劑級(jí))
| 報(bào)價(jià)日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱 | CAS號(hào) | 包裝 | 價(jià)格 |
| 2026/06/05 | HY-100676 | GRI977143; GRI-977143 GRI977143 | 325850-81-5 | 1 mg | 556元 |
| 2026/06/05 | HY-100676 | GRI977143; GRI-977143 GRI977143 | 325850-81-5 | 5 mg | 1244元 |
| 2026/06/05 | HY-100676 | GRI977143; GRI-977143 GRI977143 | 325850-81-5 | 10 mM * 1 mLin DMSO | 1368元 |
常見問(wèn)題列表
生物活性
GRI977143 是特異性的 LPA2 受體的激動(dòng)劑，其EC50 值為3.3 μM。靶點(diǎn)
|
LPA 2 Receptor 3.3 μM (EC 50 ) |
體外研究
GRI977143 (10 μM, 24-72 h) is effective in reducing activation of caspases 3, 7, 8, and 9 and inhibits poly(ADP-ribose)polymerase 1 cleavage and DNA fragmentation in different extrinsic and intrinsic models of apoptosis.
GRI977143 is an effective stimulator of extracellular signal-regulated kinase 1/2 activation and promotes the assembly of a macromolecular signaling complex consisting of LPA2, Na+-H+ exchange regulatory factor 2, and thyroid receptor interacting protein 6.
Cell Proliferation Assay
| Cell Line: | Vector- and LPA2-transduced MEF cells (2 × 10 4 ) [1] . |
| Concentration: | 10 μM. |
| Incubation Time: | 24-72 h. |
| Result: | Did not cause a significant increase in vector cell proliferation except at 72 h (p < 0.05). |
Apoptosis Analysis.
| Cell Line: | Doxorubicin-induced apoptotic signaling in vector-transduced or LPA2-transduced MEF. |
| Concentration: | 10 μM. |
| Incubation Time: | 24 h. |
| Result: |
Reduced caspase 3 and 7 activation on LPA2-transduced MEF cells by 51 ± 3% and was approximately as potent as 3 μM LPA or OTP.
Protected against doxorubicin-induced apoptosis by inhibiting caspase 3, 7, 8, and 9 and reducing DNA fragmentation. |