328898-40-4
328898-40-4 結構式
基本信息
泰地羅新溶液,100PPM
TILDIPIROSIN泰地羅新
泰地羅新 >95% BY HPLC
tildipirosin
Tildipirosin USP/EP/BP
TILDIPIROSIN 328898-40-4
TIP
TILDIPIROSIN
ZUPREVO.
Tildipirosin Solution, 100ppm
20-Deoxo-23-deoxy-5-O-[3,6-dideoxy-3-(dimethylamino)-beta-D-glucopyranosyl]-20,23-di-1-piperidinylty
Tylonolide, 20-deoxo-23-deoxy-5-O-[3,6-dideoxy-3-(dimethylamino)-β-D-glucopyranosyl]-20,23-di-1-piperidinyl-
20-Deoxo-23-deoxy-5-O-[3,6-dideoxy-3-(dimethylamino)-beta-D-glucopyranosyl]-20,23-di-1-piperidinyltylonolide
物理化學性質(zhì)
常見問題列表
泰地羅新具有特殊的三氮結構，注射后吸收更迅速，細菌外壁穿透能力更強，與細菌核糖體蛋白結合位點更多，從而使其抑菌和殺菌的作用比一般的大環(huán)內(nèi)酯類抗生素更強。同時其特殊的三氮結構可以延長泰地羅新在肺組織和支氣管液中有效濃度時間。
泰地羅新是廣譜抗菌藥，對一些革蘭氏陽性和革蘭氏陰性細菌均具有抗菌活性，對引起豬、牛呼吸系統(tǒng)疾病的病原菌尤其敏感，如胸膜肺炎放線桿菌、多殺性巴氏桿菌、支氣管敗血波氏桿菌、副豬嗜血桿菌以及溶血性曼海姆菌、睡眠嗜組織菌等。
Tildipirosin exhibits the inhibitory effect on C. coli species, and 23 of 31 (74%) isolates have MICs of 8 or 16 μg/mL while 8 of 31 (26%) have MIC >256 μg/mL. MICs against C. jejuni are 8-64 μg/mL. Tildipirosin against S. enterica and E. coli are 2-8 μg/mL. Tildipirosin inhibits the treponeme isolates form from CODD lesions from 19 sheep, with MIC90 of 0.0469 mg/L. The P. multocida B130 clones show the MIC of 0.25 mg/L for tildipirosin. The 10 P. multocida isolates that carry only erm(42) exhibit MIC of 16-32 mg/L for tildipirosin. The single M. haemolytica that harbours only erm(42) shows MIC of 32 mg/L for tildipirosin.
The mean percentage of lung consolidation for tildipirosin (4 mg/kg, s.c.)-treated calves is significantly lower than those for tulathromycin-treated and control calves. Metaphylactic administration of tildipirosin to calves 5 days prior to H somni challenge prevents subsequent culture of the pathogen from bronchial secretions and is more effective in minimizing clinical disease and lung lesions than is metaphylactic administration of tulathromycin.