335165-68-9
中文名稱
BAI1
英文名稱
3,6-DIBROMO-ALPHA-(1-PIPERAZINYLMETHYL)-9H-CARBAZOLE-9-ETHANOL DIHYDROCHLORIDE
CAS
335165-68-9
分子式
C19H21Br2N3O
分子量
467.2
MOL 文件
335165-68-9.mol
更新日期
2026/05/25 16:59:39
335165-68-9 結(jié)構(gòu)式
基本信息
中文別名
1-(3,6-二溴-9H-咔唑-9-基)-3-(哌嗪-1-基)丙-2-醇3,6-二溴吲哚-ALPHA-(1-哌嗪甲基)-9H-咔唑-9-乙醇雙鹽酸鹽
英文別名
Bax channel blocke)-3-(piperazin-1-yL
BAX CHANNEL BLOCKER
Baxchannelblocker2HCl
1-(3,6-Dibromo-9H-carbazoL
Bax channel blocker(BAI-1)
9H-Carbazole-9-ethanol, 3,6-dibromo-α-(1-piperazinylmethyl)-
1-(3,6-Dibromo-9H-carbazol-9-yl)-3-(piperazin-1-yl)propan-2-ol
3,6-Dibromo-α-(1-piperazinylmethyl)-9H-carbazole-9-ethanoldihydrochloride
3,6-DIBROMO-ALPHA-(1-PIPERAZINYLMETHYL)-9H-CARBAZOLE-9-ETHANOL DIHYDROCHLORIDE
所屬類別
生物化工：抑制劑物理化學(xué)性質(zhì)
沸點(diǎn)388.1±42.0 °C(Predicted)
密度1.71±0.1 g/cm3(Predicted)
儲(chǔ)存條件Keep in dark place,Inert atmosphere,Room temperature
溶解度≥28.2 mg/mL in DMSO with ultrasonic; insoluble in EtOH; insoluble in H2O
酸度系數(shù)(pKa)14.48±0.20(Predicted)
形態(tài)固體
顏色白色
InChIInChI=1S/C19H21Br2N3O.2ClH/c20-13-1-3-18-16(9-13)17-10-14(21)2-4-19(17)24(18)12-15(25)11-23-7-5-22-6-8-23;;/h1-4,9-10,15,22,25H,5-8,11-12H2;2*1H
InChIKeyHWFKCAFKXZFOQT-UHFFFAOYSA-N
SMILESC12=CC=C(Br)C=C1C1=C(C=CC(Br)=C1)N2CC(O)CN1CCNCC1.Cl.Cl
BAI1價(jià)格(試劑級(jí))
| 報(bào)價(jià)日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱 | CAS號(hào) | 包裝 | 價(jià)格 |
| 2026/06/05 | HY-103269 | BAI1 BAI1 | 335165-68-9 | 1 mg | 400元 |
| 2026/06/05 | HY-103269 | BAI1 BAI1 | 335165-68-9 | 5 mg | 800元 |
| 2026/06/05 | HY-103269 | BAI1 BAI1 | 335165-68-9 | 10 mM * 1 mL in DMSO | 822元 |
常見問題列表
生物活性
BAI1是一種直接的BAX變構(gòu)抑制劑，Kd值為15.0 ± 4 μM。靶點(diǎn)
| Target | Value |
|
Bax
(Cell-free assay) | 15.0 μM(Kd) |
體外研究
BAI1 selectively inhibits BAX-mediated apoptotic cell death.
BAI1 shows inhibition of tBID (HY-100464)-induced BAX-mediated membrane permeabilization in a dose dependent manner with an IC
50
of 3.3 μΜ.
Apoptosis Analysis
| Cell Line: | Mouse MEF |
| Concentration: | 0.3125 μM , 0.625 μM, 1 μM, 1.25 μM, 1.5 μM, 2.5 μM , 3 μM, 4 μM, 5 4 μM, 10 4 μM |
| Incubation Time: | 8 hours |
| Result: | Inhibited cell death in BAX-dependent manner. |