344897-95-6

中文名稱 4-(5-((3-芐基-4-氧代-2-硫代噻唑烷-5-亞基)甲基)呋喃-2-基)苯甲酸

英文名稱 Leukadherin 1

CAS 344897-95-6

分子式 C22H15NO4S2

分子量 421.49

MOL 文件 344897-95-6.mol

更新日期 2026/07/18 15:26:30

344897-95-6 結(jié)構(gòu)式

基本信息物理化學(xué)性質(zhì) 安全數(shù)據(jù) 圖譜信息 4-(5-((3-芐基-4-氧代-2-硫代噻唑烷-5-亞基)甲基)呋喃-2-基)苯甲酸價(jià)格(試劑級(jí)) 常見問(wèn)題列表

基本信息

中文別名

4-(5-((3-芐基-4-氧代-2-硫代噻唑烷-5-亞基)甲基)呋喃-2-基)苯甲酸

英文別名

CS-2237
eukadherin-1
Leukadherin-1
Leukadherin 1
Leukadhedrin 1
LA1(Leukadherin-1)
LEUKADHERIN 1
LEUKADHERIN1
4-(5-((3-Benzyl-4-oxo-2-thioxothiazolidin-5-ylidene)methyl)furan-2-yl)benzoic acid
4-[5-[[4-Oxo-3-(phenylmethyl)-2-thioxo-5-thiazolidinylidene]methyl]-2-furanyl]-benzoic acid
Benzoic acid, 4-[5-[[4-oxo-3-(phenylmethyl)-2-thioxo-5-thiazolidinylidene]methyl]-2-furanyl]-

所屬類別

生物化工：激動(dòng)劑抑制劑

物理化學(xué)性質(zhì)

沸點(diǎn)634.7±65.0 °C(Predicted)

密度1.50±0.1 g/cm3(Predicted)

儲(chǔ)存條件Sealed in dry,2-8°C

溶解度DMSO：可溶，3mg/mL，澄清（加熱）

酸度系數(shù)(pKa)4.11±0.10(Predicted)

形態(tài)粉末

顏色黃色到橙色到棕色

InChI1S/C22H15NO4S2/c24-20-19(29-22(28)23(20)13-14-4-2-1-3-5-14)12-17-10-11-18(27-17)15-6-8-16(9-7-15)21(25)26/h1-12H,13H2,(H,25,26)/b19-12-

InChIKeyAEZGRQSLKVNPCI-UNOMPAQXSA-N

SMILESS1\C(=C/c3[o]c(cc3)c4ccc(cc4)C(=O)O)\C(=O)N(C1=S)Cc2ccccc2

安全數(shù)據(jù)

危險(xiǎn)性符號(hào)(GHS) 有害 (GHS07)

GHS07,GHS08,GHS09

警示詞危險(xiǎn)

危險(xiǎn)性描述H302-H410-H372

防范說(shuō)明P260-P264-P273-P501

WGK Germany3

存儲(chǔ)類別11 - Combustible Solids

圖譜信息

4-(5-((3-芐基-4-氧代-2-硫代噻唑烷-5-亞基)甲基)呋喃-2-基)苯甲酸(344897-95-6)核磁圖(¹HNMR)

4-(5-((3-芐基-4-氧代-2-硫代噻唑烷-5-亞基)甲基)呋喃-2-基)苯甲酸價(jià)格(試劑級(jí))

報(bào)價(jià)日期	產(chǎn)品編號(hào)	產(chǎn)品名稱	CAS號(hào)	包裝	價(jià)格
2026/06/05	HY-15701R	4-(5-((3-芐基-4-氧代-2-硫代噻唑烷-5-亞基)甲基)呋喃-2-基)苯甲酸 Leukadherin-1 (Standard)	344897-95-6	5 mg	900元
2026/06/05	HY-15701R	4-(5-((3-芐基-4-氧代-2-硫代噻唑烷-5-亞基)甲基)呋喃-2-基)苯甲酸 Leukadherin-1 (Standard)	344897-95-6	10 mg	1476元
2026/06/05	HY-15701R	4-(5-((3-芐基-4-氧代-2-硫代噻唑烷-5-亞基)甲基)呋喃-2-基)苯甲酸 Leukadherin-1 (Standard)	344897-95-6	25 mg	2952元

常見問(wèn)題列表

生物活性

Leukadherin-1 是特異性的白細(xì)胞表面整合素 CD11b/CD18 的激動(dòng)劑。Leukadherin-1 可增加 CD11b/CD18 依賴性細(xì)胞對(duì)血纖蛋白原的粘附，EC50為 4 μM。Leukadherin-1 增強(qiáng)白細(xì)胞對(duì)配體 (如 ICAM-1) 和血管內(nèi)皮的粘附，從而減少白細(xì)胞跨內(nèi)皮遷移和流入損傷部位。Leukadherin-1 抑制先天性炎癥信號(hào)轉(zhuǎn)導(dǎo)。

體外研究

Leukadherin-1 is a specific agonist of the leukocyte surface integrin CD11b/CD18 (αMβ2; CR3; Mac-1). Leukadherin‐1 pretreatment reduces secretion of interferon (IFN)‐γ, tumour necrosis factor (TNF) and macrophage inflammatory protein (MIP)‐1β by monokine‐stimulated NK cells. Leukadherin‐1 pretreatment also reduces secretion of IL‐1β, IL‐6 and TNF by Toll‐like receptor (TLR)‐2 and TLR‐7/8‐stimulated monocytes.

體內(nèi)研究

Leukadherin-1 (1 mg/kg; i.p.; twice daily for 14 days) is beneficial in preventing hyperoxia-induced neonatal lung injury, an experimental model of bronchopulmonary dysplasia (BPD).

Animal Model:	Newborn Sprague Dawley rat pups
Dosage:	1 mg/kg
Administration:	I.p.; twice daily for 14 days
Result:	Beneficial on preventing the lung inflammatory response, improved alveolarization and vascular development, and reduced pulmonary vascular remodeling and PH in a hyperoxia-induced experimental model of BPD.