35286-59-0
中文名稱
地榆皂苷Ⅱ
英文名稱
Ziyuglycoside II
CAS
35286-59-0
分子式
C35H56O8
分子量
604.83
MOL 文件
35286-59-0.mol
更新日期
2026/07/23 10:10:01
35286-59-0 結構式
基本信息
中文別名
地榆甙II地榆皂苷LL
地榆皂苷 II
地榆皂苷II對照品,
地榆皂苷II、地榆苷Ⅱ
地榆皂苷II(標準品)
英文別名
Gouguside 1Ziyuglycoside
Ziyuglycoside II
Zigu-glucoside II
(3β)-3-(α-L-Arabinopyranosyloxy)-19-hydroxyurs-12-en-28-oicaci
(3β)-3-(α-L-Arabinopyranosyloxy)-19-hydroxyurs-12-en-28-oic acid
Urs-12-en-28-oic acid, 3-(α-L-arabinopyranosyloxy)-19-hydroxy-, (3β)-
(3beta)-3-(alpha-L-Arabinopyranosyloxy)-19-hydroxyurs-12-en-28-oic acid
所屬類別
天然產(chǎn)物：萜類物理化學性質(zhì)
外觀性狀白色結晶體，可溶于甲醇、乙醇、DMSO等有機溶劑，來源于地榆。
熔點260-263℃
沸點716.2±60.0 °C(Predicted)
密度1.25
儲存條件-20°C, protect from light
溶解度Soluble in DMSO and methanol;
酸度系數(shù)(pKa)4.47±0.70(Predicted)
形態(tài)粉末
顏色White to off-white
水溶解性不溶于水
InChIKeyMFIXLWYJTVEVGO-VHOGPVSJNA-N
SMILESC[C@]12CC[C@H](O[C@]3([H])OC[C@H](O)[C@H](O)[C@H]3O)C(C)(C)[C@]1([H])CC[C@]4(C)[C@]2([H])CC=C5[C@@]4(C)CC[C@]6(C(O)=O)[C@@]5([H])[C@@](O)(C)[C@H](C)CC6
地榆皂苷Ⅱ價格(試劑級)
| 報價日期 | 產(chǎn)品編號 | 產(chǎn)品名稱 | CAS號 | 包裝 | 價格 |
| 2026/06/05 | HY-N0332 | 地榆皂苷Ⅱ Ziyuglycoside II | 35286-59-0 | 5mg | 550元 |
| 2026/06/05 | HY-N0332 | 地榆皂苷Ⅱ Ziyuglycoside II | 35286-59-0 | 10 mM * 1 mL in DMSO | 732元 |
| 2026/06/05 | HY-N0332 | 地榆皂苷Ⅱ Ziyuglycoside II | 35286-59-0 | 10mg | 950元 |
常見問題列表
生物活性
Ziyuglycoside II 是從 Sanguisorba officinalis L. 中提取的三萜皂苷化合物。Ziyuglycoside II 誘導活性氧 (ROS) 產(chǎn)生和凋亡 (apoptosis)。 具有抗炎和抗癌作用。體外研究
Ziyuglycoside II (10-60 μM; 24 h and 48 h) inhibits MDA-MB-435 cells growth in a dose-dependent manner. The IC
50
of Ziyuglycoside II at 24 h and 48 h is 5.92 μM and 4.74 μM, respectively.
Ziyuglycoside II (5-25 μM) induces G0/G1 and S phase arrest in MDA-MB-435 cells at 24 h.
Ziyuglycoside II (5-25 μM; 24 hours) significantly increases apoptotic rate of MDA-MB-435 cells.
Ziyuglycoside II (5-25 μM; 24 hours) increases expressions of both p53 and p21 in MDA-MB-435 cells, which effect is dose-dependent.
Cell Viability Assay
| Cell Line: | MDA-MB-435 cells |
| Concentration: | 10, 20, 30, 40, 50, 60 μM |
| Incubation Time: | 24 hours and 48 hours |
| Result: | The IC 50 at 24 h and 48 h was 5.92 μM and 4.74 μM, respectively. |
Cell Cycle Analysis
| Cell Line: | MDA-MB-435 cells |
| Concentration: | 5, 10, 25 μM |
| Incubation Time: | 24 hours |
| Result: | Induced G0/G1 and S phase arrest. |
Apoptosis Analysis
| Cell Line: | MDA-MB-435 cells |
| Concentration: | 5, 10, 25 μM |
| Incubation Time: | 24 hours |
| Result: | The apoptotic rate was significantly increased in comparison to that of the control. |
Western Blot Analysis
| Cell Line: | MDA-MB-435 cells |
| Concentration: | 5, 10, 25 μM |
| Incubation Time: | 24 hours |
| Result: | Treatment resulted in increased expressions of both p53 and p21. |