36098-33-6
中文名稱
F16
英文名稱
F16
CAS
36098-33-6
分子式
C16H15IN2
分子量
362.21
MOL 文件
36098-33-6.mol
更新日期
2024/12/03 15:40:34
36098-33-6 結(jié)構(gòu)式
基本信息
中文別名
細胞增殖抑制劑(F16)4-[(E)-2-(1H-吲哚-3-基)乙烯基]-1-甲基吡啶鎓碘化物
英文別名
F16F16 (F-16
Compound F16)
F-16
COMPOUND F16
F16/Cell proliferation inhibitor (F16)
4-[(E)-2-(INDOL-3-YL)ETHENYL]-N-METHYLPYRIDINIUM IODIDE
3-[2-(1-methylpyridin-1-ium-4-yl)ethenyl]-1H-indole,iodide
4-[(1E)-2-(1H-INDOL-3-YL)ETHENYL]-1-METHYL-PYRIDINIUM IODIDE
物理化學(xué)性質(zhì)
儲存條件-20°C儲存
溶解度≤500μg/ml in ethanol;20mg/ml in DMSO;25mg/ml in dimethyl formamide
形態(tài)橙色固體
顏色Yellow to orange
F16價格(試劑級)
| 報價日期 | 產(chǎn)品編號 | 產(chǎn)品名稱 | CAS號 | 包裝 | 價格 |
| 2026/06/05 | HY-100395 | F16 | 36098-33-6 | 5 mg | 343元 |
| 2026/06/05 | HY-100395 | F16 F16 | 36098-33-6 | 10mM * 1mLin DMSO | 377元 |
| 2026/06/05 | HY-100395 | F16 F16 | 36098-33-6 | 10mg | 550元 |
常見問題列表
生物活性
F16 是 neu 過表達細胞的有效生長抑制劑，還可以選擇性抑制乳腺上皮以及多種小鼠乳腺腫瘤和人乳腺癌細胞系的增殖。F16 是線粒體毒性化合物，根據(jù)靶癌細胞的遺傳背景觸發(fā)凋亡或壞死。體外研究
F16 (3 μM; 3 days/7 days) affects growth in several mouse and human cancer cell lines.
F16 arrests cell cycle and increases apoptosis in F16-sensitive EpH4-A6 cells.
Cell Proliferation Assay
| Cell Line: | MDA-MB231, MDA-MB435, MDA-MB436, MDA-MB453, MDA-MB-468, SKBR-3, MCF-7, T47D, ZR-75-1 cells and mouse mammary epithelial cell line NMuMG |
| Concentration: | 3 μM |
| Incubation Time: | 3 days/7 days |
| Result: | Displayed antiproliferative activity against both mouse and human breast cancer cells. The growth of the mouse fibrosarcoma cell lines derived from ras -transgenic mice was not affected. |