36098-33-6
中文名稱
F16
英文名稱
F16
CAS
36098-33-6
分子式
C16H15IN2
分子量
362.21
MOL 文件
36098-33-6.mol
更新日期
2024/12/03 15:40:34
36098-33-6 結(jié)構(gòu)式
基本信息
中文別名
細(xì)胞增殖抑制劑(F16)4-[(E)-2-(1H-吲哚-3-基)乙烯基]-1-甲基吡啶鎓碘化物
英文別名
F16F16 (F-16
Compound F16)
F-16
COMPOUND F16
F16/Cell proliferation inhibitor (F16)
4-[(E)-2-(INDOL-3-YL)ETHENYL]-N-METHYLPYRIDINIUM IODIDE
3-[2-(1-methylpyridin-1-ium-4-yl)ethenyl]-1H-indole,iodide
4-[(1E)-2-(1H-INDOL-3-YL)ETHENYL]-1-METHYL-PYRIDINIUM IODIDE
物理化學(xué)性質(zhì)
儲存條件-20°C儲存
溶解度≤500μg/ml in ethanol;20mg/ml in DMSO;25mg/ml in dimethyl formamide
形態(tài)橙色固體
顏色Yellow to orange
F16價格(試劑級)
| 報價日期 | 產(chǎn)品編號 | 產(chǎn)品名稱 | CAS號 | 包裝 | 價格 |
| 2026/06/05 | HY-100395 | F16 | 36098-33-6 | 5 mg | 343元 |
| 2026/06/05 | HY-100395 | F16 F16 | 36098-33-6 | 10mM * 1mLin DMSO | 377元 |
| 2026/06/05 | HY-100395 | F16 F16 | 36098-33-6 | 10mg | 550元 |
常見問題列表
生物活性
F16 是 neu 過表達(dá)細(xì)胞的有效生長抑制劑，還可以選擇性抑制乳腺上皮以及多種小鼠乳腺腫瘤和人乳腺癌細(xì)胞系的增殖。F16 是線粒體毒性化合物，根據(jù)靶癌細(xì)胞的遺傳背景觸發(fā)凋亡或壞死。體外研究
F16 (3 μM; 3 days/7 days) affects growth in several mouse and human cancer cell lines.
F16 arrests cell cycle and increases apoptosis in F16-sensitive EpH4-A6 cells.
Cell Proliferation Assay
| Cell Line: | MDA-MB231, MDA-MB435, MDA-MB436, MDA-MB453, MDA-MB-468, SKBR-3, MCF-7, T47D, ZR-75-1 cells and mouse mammary epithelial cell line NMuMG |
| Concentration: | 3 μM |
| Incubation Time: | 3 days/7 days |
| Result: | Displayed antiproliferative activity against both mouse and human breast cancer cells. The growth of the mouse fibrosarcoma cell lines derived from ras -transgenic mice was not affected. |